Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
| Title: | Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes |
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| Authors: | S Vogelezang; JP Bradfield; S Johansson; E Stergiakouli; E Thiering; CE Pennell; TS Ahluwalia; V Karhunen; M Scholz; X Liu; C Iñiguez; OT Raitakari; J Bacelis; TM Schnurr; TA Lakka; I Ntalla; MV Lind; L Lauritzen; S Herrala; FTJ Lin; C Frithioff-Bøjsøe; RN Beaumont; MH Zafarmand; P Rzehak; JR Bilbao; N Junna; JM Vonk; SL Rifas-Shiman; VD Janjanam; MJ Knol; S Ramdas; L Beilin; K Bønnelykke; M Casas; JG Eriksson; J Escribano; TE Evans; U Gehring; F Geller; V Grote; D Gruszfeld; H Hakonarson; AT Hattersley; CT Have; M Geoffrey Hayes; J Heinrich; Ø Helgeland; J Holloway; R Joro; J Juodakis; BA Knight; B Koletzko; A Körner; J-P Langhendries; JT Leinonen; V Lindi; MAV Lund; S Lye; M Melbye; KF Michaelsen; CS Morgen; H Niinikoski; K Pahkala; K Panoutsopoulou; O Pedersen; F Rivadeneira; L Santa-Marina; BDC Schaik; D Scholtens; S Sebert; I Tamayo; NJ Timpson; M Torrent; AG Uitterlinden; M Vaudel; E Verduci; R Vinding; M Vogel; E Zeggini; C Brown; HHH Adams; W Karmaus; M-F Hivert; GH Koppelman; E Widén; N Fernandez-Jimenez; M Waldenberger; TGM Vrijkotte; RM Freathy; J-C Holm; WL Lowe; N Grarup; T Hansen; GV Dedoussis; M Atalay; EA Nohr; B Jacobsson; N Pitkänen; M Vrijheid; B Feenstra; W Kiess; M-R Jarvelin; H Bisgaard; C Wang C; M Standl; MI McCarthy; BS Pourcain; PR Njølstad; SFA Grant; JF Felix; VWV Jaddoe |
| Publication Year: | 2022 |
| Collection: | Erasmus University Rotterdam (EUR): Figshare |
| Subject Terms: | Head circumference; Genome-wide association study; Genetic correlations; Infancy |
| Description: | Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide signifcance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics. |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | 10871/129879 |
| Availability: | https://figshare.com/articles/journal_contribution/Genetics_of_early-life_head_circumference_and_genetic_correlations_with_neurological_psychiatric_and_cognitive_outcomes/29787749 |
| Rights: | CC BY |
| Accession Number: | edsbas.C1E4B680 |
| Database: | BASE |