| Title: |
Role of neutrophil-lymphocyte ratio in the prognosis of acute ischaemic stroke after reperfusion therapy : a systematic review and meta-analysis |
| Authors: |
Sharma, Divyansh; Spring, Kevin J. (R17176); Bhaskar, Sonu M. |
| Publisher Information: |
U.K., Sage Publications |
| Publication Year: |
2022 |
| Collection: |
University of Western Sydney (UWS): Research Direct |
| Subject Terms: |
XXXXXX - Unknown |
| Description: |
Background: Inflammation may mediate response to acute reperfusion therapy (RT) in acute cerebral ischaemia. Neutrophil-lymphocyte ratio (NLR), an inflammatory biomarker, may play an important role in acute ischaemic stroke (AIS) prognostication. Objective: This meta-analysis sought to examine the effect of NLR on functional outcomes, mortality and adverse outcomes in AIS patients receiving RT. Methods: Individual studies were retrieved from PubMed/Medline, EMBASE and Cochrane databases. Data were extracted using a standardised data sheet and meta-analysis on association of admission (pre-RT) or delayed (post-RT) NLR with clinical/safety outcomes after RT was conducted. Results: Thirty-five studies (n = 10Â 308) were identified for the systematic review with 27 (n = 8537) included in the meta-analyses. Lower admission NLR was associated with good functional outcomes (GFOs), defined as 3-month modified Rankin scale (mRS) 0–2 (SMD = −.46; 95% CI = −.62 to −.29; P |
| Document Type: |
article in journal/newspaper |
| File Description: |
print |
| Language: |
English |
| Relation: |
Journal of Central Nervous System Disease--1179-5735-- Vol. 14 Issue. No. pp: - |
| DOI: |
10.1177/11795735221092518 |
| Availability: |
https://doi.org/10.1177/11795735221092518; https://hdl.handle.net/1959.7/uws:77842 |
| Rights: |
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Accession Number: |
edsbas.C1FE4B52 |
| Database: |
BASE |