| Title: |
Quantification of Bioactive Compounds by HPLC-ESI-MS/MS and Evaluation of Antioxidant and Enzyme Inhibitory Activities of Acorn Flour Extracts |
| Authors: |
Laura, Acquaticci; Agnese, Santanatoglia; Elena, Vittadini; Daniela, Beghelli; Antonietta, La Terza; Gokhan, Zengin; Giovanni, Caprioli |
| Contributors: |
Acquaticci, Laura; Santanatoglia, Agnese; Vittadini, Elena Giovanna Piera; Beghelli, Daniela; LA TERZA, Antonietta; Zengin, Gokhan; Caprioli, Giovanni |
| Publication Year: |
2024 |
| Collection: |
CAMPUS Pubblicazioni Scientifiche Unicam (Università di Camerino) |
| Description: |
This study provides the first comprehensive evaluation of the bioactive potential of acorn flour extracts (Quercus robur, Fagaceae) prepared at different temperatures (20, 60, 80 and 100 ◦C), focusing on polyphenolic content, antioxidant properties and enzyme inhibitory activities. Through HPLC-ESI-MS/MS analysis, 36 bioactive compounds were identified, with the extract at 60 ◦C showing the highest concentrations of key polyphenols, notably gallic acid (210,008.9 mg·kg−1) and ellagic acid (45,469.6 mg·kg−1). This extract also exhibited a high antioxidant activity and significant inhibition of glucosidase and acetylcholinesterase, suggesting potential benefits for diabetes management and neuroprotection. The results indicate that extraction temperature affects bioactivity, with the 60 ◦C extract standing out as a promising candidate for nutraceutical, pharmaceutical, and cosmeceutical applications due to its rich polyphenol profile and potent biological properties. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001384281900001; volume:13; issue:12; firstpage:1; lastpage:12; numberofpages:12; journal:ANTIOXIDANTS; https://hdl.handle.net/11581/487843 |
| DOI: |
10.3390/antiox13121526 |
| Availability: |
https://hdl.handle.net/11581/487843; https://doi.org/10.3390/antiox13121526; https://www.mdpi.com/2076-3921/13/12/1526 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:PUBBLICO - Creative Commons ; license uri:iris.PUB17 |
| Accession Number: |
edsbas.C204533 |
| Database: |
BASE |