| Title: |
Spectral CT data acquisition with Medipix3.1 |
| Authors: |
Walsh, MF; Nik, SJ; Procz, S; Pichotka, M; Bell, ST; Bateman, CJ; Doesburg, RMN; Ruiter De, N; Chernoglazov, AI; Panta, RK; Butler, APH; Butler, PH |
| Publisher Information: |
IOP Publishing on behalf of Sissa Medialab |
| Collection: |
Lincoln University (New Zealand): Lincoln U Research Archive |
| Subject Terms: |
computerised tomography (CT); computerised radiography (CR); data acquisition concepts; ANZSRC::11 Medical and Health Sciences; ANZSRC::110320 Radiology and Organ Imaging; ANZSRC::40 Engineering; ANZSRC::51 Physical sciences |
| Description: |
This paper describes the acquisition of spectral CT images using the Medipix3.1 in spectroscopic mode, in which the chip combines 2 ×2 pixel clusters to increase the number of energy thresholds and counters from 2 to 8. During preliminary measurements, it was observed that the temperature, DAC and equalisation stability of the Medipix3.1 outperformed the Medipix3.0, while maintaining similar imaging quality. In this paper, the Medipix3.1 chips were assembled in a quad (2×2) layout, with the four ASICs bump-bonded to a silicon semiconductor doped as an np-junction diode. To demonstrate the biological imaging quality that is possible with the Medipix3.1,an image of a mouse injected with gold nano-particle contrast agent was obtained. CT acquisition in spectroscopic mode was enabled and examined by imaging a customised phantom containing multiple contrast agents and biological materials. These acquisitions showed a limitation of imaging performance depending on the counter used. Despite this, identification of multiple materials in the phantom was demonstrated using an in-house material decomposition algorithm. Furthermore,gold nano-particles were separated from biological tissues and bones within the mouse by means of image rendering. |
| Document Type: |
article in journal/newspaper |
| File Description: |
12 pages |
| Language: |
English |
| Relation: |
The original publication is available from IOP Publishing on behalf of Sissa Medialab - https://doi.org/10.1088/1748-0221/8/10/P10012 - https://doi.org/10.1088/1748-0221/8/10/p10012; Journal of Instrumentation; https://doi.org/10.1088/1748-0221/8/10/P10012; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000326930900036&DestLinkType=FullRecord&DestApp=WOS_CPL; 251LR (isidoc); https://hdl.handle.net/10182/9285 |
| DOI: |
10.1088/1748-0221/8/10/P10012 |
| Availability: |
https://hdl.handle.net/10182/9285; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000326930900036&DestLinkType=FullRecord&DestApp=WOS_CPL; https://doi.org/10.1088/1748-0221/8/10/P10012 |
| Rights: |
Published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI. ; https://creativecommons.org/licenses/by/4.0/ ; Attribution |
| Accession Number: |
edsbas.C22DB5CF |
| Database: |
BASE |