| Title: |
Reduced glutamate in white matter of male neonates exposed to alcohol in utero: a 1H-magnetic resonance spectroscopy study |
| Authors: |
Howells, FM; Donald, KA; Roos, A; Woods, RP; Zar, HJ; Narr, KL; Stein, DJ |
| Source: |
Metabolic Brain Disease, vol 31, iss 5 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Paediatrics; Biomedical and Clinical Sciences; Intellectual and Developmental Disabilities (IDD); Conditions Affecting the Embryonic and Fetal Periods; Clinical Research; Alcoholism; Alcohol Use and Health; Fetal Alcohol Spectrum Disorders (FASD); Neurosciences; Pediatric; Substance Misuse; Perinatal Period - Conditions Originating in Perinatal Period; Brain Disorders; Good Health and Well Being; Alcohol Drinking; Cohort Studies; Female; Glutamic Acid; Humans; Infant; Newborn; Magnetic Resonance Spectroscopy; Male; Pregnancy; Prenatal Exposure Delayed Effects; Protons; Sex Characteristics; White Matter; MRS; Alcohol exposure |
| Time: |
1105 - 1112 |
| Description: |
In utero exposure to alcohol leads to a spectrum of fetal alcohol related disorders (FASD). However, few studies used have used proton magnetic resonance spectroscopy ((1)H-MRS) to understand how neurochemical disturbances relate to the pathophysiology of FASD. Further, no studies to date have assessed brain metabolites in infants exposed to alcohol in utero. We hypothesize that neonates exposed to alcohol in utero will show decreased glutamatergic activity, pre-emptive of their clinical diagnosis or behavioural phenotype. Single voxel (1)H-MRS data, sampled in parietal white and gray matter, were acquired from 36 neonates exposed to alcohol in utero, and 31 control unexposed healthy neonates, in their 2nd-4th week of life. Metabolites relative to creatine with phosophocreatine and metabolites absolute concentrations using a water reference are reported. Male infants exposed to alcohol in utero were found to have reduced concentration of glutamate with glutamine (Glx) in their parietal white matter (PWM), compared to healthy male infants (p=0.02). Further, male infants exposed to alcohol in utero had reduced concentration and ratio for glutamate (Glu) in their PWM (p=0.02), compared to healthy male infants and female infants exposed to alcohol in utero. Female infants showed higher relative Glx and Glu ratios for parietal gray matter (PGM, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt0m26f2kt; https://escholarship.org/uc/item/0m26f2kt; https://escholarship.org/content/qt0m26f2kt/qt0m26f2kt.pdf |
| DOI: |
10.1007/s11011-016-9850-x |
| Availability: |
https://escholarship.org/uc/item/0m26f2kt; https://escholarship.org/content/qt0m26f2kt/qt0m26f2kt.pdf; https://doi.org/10.1007/s11011-016-9850-x |
| Rights: |
public |
| Accession Number: |
edsbas.C24A6D53 |
| Database: |
BASE |