| Title: |
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK |
| Authors: |
Bloom, CI; Drake, TM; Docherty, AB; Lipworth, BJ; Johnston, SL; Nguyen-Van-Tam, JS; Carson, G; Dunning, J; Harrison, EM; Baillie, JK; Semple, MG; Cullinan, P; Openshaw, PJM; Alex, B; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Cooke, GS; Filipe, AD; Fletcher, T; Green, CA; Hiscox, JA; Ho, AY; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lim, WS; Mentzer, AJ; Merson, L; Meynert, AM; Noursadeghi, M; Moore, SC; Palmarini, M; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Russell, CD; Sancho-Shimizu, V; Scott, JT; Silva, TD; Sigfrid, L; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Tedder, RS; Thomson, EC; Thompson, AAR; Thwaites, RS; Turtle, LCW; Zambon, M; Hardwick, H; Donohue, C; Lyons, R; Griffiths, F; Oosthuyzen, W; Norman, L; Pius, R; Fairfield, CJ; Knight, SR; Mclean, KA; Murphy, D; Shaw, CA; Dalton, J; Girvan, M; Saviciute, E; Roberts, S; Harrison, J; Marsh, L; Connor, M; Halpin, S; Jackson, C; Gamble, C; Leeming, G; Wham, M; Clohisey, S; Hendry, R; Scott-Brown, J; Greenhalf, W; Shaw, V; McDonald, S; Keating, S; Ahmed, KA; Armstrong, JA; Ashworth, M; Asiimwe, IG; Bakshi, S; Barlow, SL; Booth, L; Brennan, B; Bullock, K; Catterall, BWA; Clark, JJ; Clarke, EA; Cole, S; Cooper, L; Cox, H; Davis, C; Dincarslan, O; Dunn, C; Dyer, P; Elliott, A; Evans, A; Finch, L; Fisher, LWS; Foster, T; Garcia-Dorival, I; Gunning, P; Hartley, C; Jensen, RL; Jones, CB; Jones, TR; Khandaker, S; King, K; Kiy, RT; Koukorava, C; Lake, A; Lant, S; Latawiec, D; Lavelle-Langham, L; Lefteri, D; Lett, L; Livoti, LA; Mancini, M; McEvoy, L; McLauchlan, J; Metelmann, S; Miah, NS; Middleton, J; Mitchell, J; Murphy, EG; Penrice-Randal, R; Pilgrim, J; Prince, T; Reynolds, W; Ridley, PM; Sales, D; Shaw, VE; Shears, RK; Small, B; Subramaniam, KS; Szemiel, A; Taggart, A; Tanianis-Hughes, J; Thomas, J; Trochu, E; Tonder, LV; Wilcock, E; Zhang, JE; Flaherty, L; Maziere, N; Cass, E; Carracedo, AD; Carlucci, N; Holmes, A; Massey, H; Adeniji, K; Agranoff, D; Agwuh, K; Ail, D; Alegria, A; Angus, B; Ashish, A; Atkinson, D; Bari, S; Barlow, G; Barnass, S; Barrett, N; Bassford, C; Baxter, D; Beadsworth, M; Bernatoniene, J; Berridge, J; Best, N; Bothma, P; Brealey, D; Brittain-Long, R; Bulteel, N; Burden, T; Burtenshaw, A; Caruth, V; Chadwick, D; Chambler, D; Chee, N; Child, J; Chukkambotla, S; Clark, T; Collini, P; Cosgrove, C; Cupitt, J; Cutino-Moguel, M; Dark, P; Dawson, C; Dervisevic, S; Donnison, P; Douthwaite, S; DuRand, I; Dushianthan, A; Dyer, T; Evans, C; Eziefula, C; Fegan, C; Finn, A; Fullerton, D; Garg, S; Garg, A; Gkrania-Klotsas, E; Godden, J; Goldsmith, A; Graham, C; Hardy, E; Hartshorn, S; Harvey, D; Havalda, P; Hawcutt, DB; Hobrok, M; Hodgson, L; Hormis, A; Jacobs, M; Jain, S; Jennings, P; Kaliappan, A; Kasipandian, V; Kegg, S; Kelsey, M; Kendall, J; Kerrison, C; Kerslake, I; Koch, O; Koduri, G; Koshy, G; Laha, S; Laird, S; Larkin, S; Leiner, T; Lillie, P; Limb, J; Linnett, V; Little, J; MacMahon, M; MacNaughton, E; Mankregod, R; Masson, H; Matovu, E; McCullough, K; McEwen, R; Meda, M; Mills, G; Minton, J; Mirfenderesky, M; Mohandas, K; Mok, Q; Moon, J; Moore, E; Morgan, P; Morris, C; Mortimore, K; Moses, S; Mpenge, M; Mulla, R; Murphy, M; Nagel, M; Nagarajan, T; Nelson, M; Otahal, I; Pais, M; Panchatsharam, S; Paraiso, H; Patel, B; Pattison, N; Pepperell, J; Peters, M; Phull, M; Pintus, S; Pooni, J; Post, F; Price, D; Prout, R; Rae, N; Reschreiter, H; Reynolds, T; Richardson, N; Roberts, M; Roberts, D; Rose, A; Rousseau, G; Ryan, B; Saluja, T; Shah, A; Shanmuga, P; Sharma, A; Shawcross, A; Sizer, J; Shankar-Hari, M; Smith, R; Snelson, C; Spittle, N; Staines, N; Stambach, T; Stewart, R; Subudhi, P; Szakmany, T; Tatham, K; Thompson, C; Thompson, R; Tridente, A; Tupper-Carey, D; Twagira, M; Ustianowski, A; Vallotton, N; Vincent-Smith, L; Visuvanathan, S; Vuylsteke, A; Waddy, S; Wake, R; Walden, A; Welters, I; Whitehouse, T; Whittaker, P; Whittington, A; Wijesinghe, M; Williams, M; Wilson, L; Wilson, S; Winchester, S; Wiselka, M; Wolverson, A; Wooton, DG; Workman, A; Yates, B; Young, P |
| Contributors: |
National Institute for Health Research; UK Research and Innovation; GlaxoSmithKline Biologicals; UKRI MRC COVID-19 Rapid Response Call; Medical Research Council (MRC) |
| Source: |
711 ; 699 |
| Publisher Information: |
Elsevier |
| Publication Year: |
2021 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
ISARIC investigators; Humans; Asthma; Pulmonary Disease; Chronic Obstructive; Clinical Protocols; Hospitalization; Hospital Mortality; Risk Assessment; Cohort Studies; Prospective Studies; Adolescent; Adult; Middle Aged; World Health Organization; Female; Male; Young Adult; United Kingdom; COVID-19; 1103 Clinical Sciences; 1117 Public Health and Health Services; 1199 Other Medical and Health Sciences |
| Description: |
Background Studies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated with underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed to characterise people with COVID-19 admitted to hospital with underlying respiratory disease, assess the level of care received, measure in-hospital mortality, and examine the effect of inhaled corticosteroid use. Methods We analysed data from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) study. All patients admitted to hospital with COVID-19 across England, Scotland, and Wales between Jan 17 and Aug 3, 2020, were eligible for inclusion in this analysis. Patients with asthma, chronic pulmonary disease, or both, were identified and stratified by age ( |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
The Lancet Respiratory Medicine; http://hdl.handle.net/10044/1/86567; 9815274 MC_PC_19025; PO 3001965656; NIHR201385; MC_PC19025; MR/T031565/1; 1257927 |
| DOI: |
10.1016/S2213-2600(21)00013-8 |
| Availability: |
http://hdl.handle.net/10044/1/86567; https://doi.org/10.1016/S2213-2600(21)00013-8 |
| Rights: |
© 2021 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/ ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.C27EA2A5 |
| Database: |
BASE |