| Title: |
Low dose (d1-5/7) oral etoposide regimen in intensively treated platinum-resistant epithelial ovarian cancer: The İzmir oncology group (IZOG) study |
| Authors: |
Taskaynatan, Halil; Kucukzeybek, Yuksel; Yildiz, Yasar; Salman, Tarik; Oflazoglu, Utku; Varol, Umut; Alacacioglu, Ahmet; Saray, Seray; Ozdemir, Ozlem; Tarhan, Mustafa Oktay |
| Publication Year: |
2020 |
| Collection: |
Inonu University: Akademic Archive System / İnönü Üniversitesi Akademik Arşiv Sistemi |
| Description: |
Aim: Oral etoposide dosage is roughly 50-100 mg/m2 on days 1 to 21 every 28 days. However, dosage of 50 mg/day oral etoposide for five days a week is not well published. The present study, aimed to evaluate the efficacy and toxicity profile of low dose oral etoposide regimen (50 mg/day on days 1 to 5 every week) in platinum-resistant epithelial ovarian cancer (EOC).Material and Methods: This study retrospectively evaluates patients with pathologically confirmed platinum-resistant EOC who were unable to tolerate the standard oral etoposide regimen and were on low dose (d1-5/7) oral etoposide regimen in third line or beyond within the period between 2006 and 2014.Results: The overall response rate among 33 EOC patients was 15.1% while clinical benefit rate was 42.4% (stable disease in 27.3% and partial response in 15.1%). Median progression-free survival was 4 months (95% confidence interval [CI], 2.8–5.1 months) and median overall survival was 12 months (95% CI, 8.8–15.1 months). Conclusion: We concluded that low dose oral etoposide (50 mg/day, on days 1 to 5 every week) was effective and well tolerated for platinum-resistant EOC. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Annals of Medical Research; https://hdl.handle.net/11616/54748 |
| Availability: |
https://hdl.handle.net/11616/54748 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C2AC3FDC |
| Database: |
BASE |