| Title: |
2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues |
| Authors: |
Taskesen, E. (author); Reinders, M.J.T. (author) |
| Publisher Information: |
Public Library of Science |
| Publication Year: |
2016 |
| Collection: |
Delft University of Technology: Institutional Repository |
| Subject Terms: |
OA-Fund TU Delft |
| Description: |
The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships. ; Intelligent Systems ; Electrical Engineering, Mathematics and Computer Science |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
PLoS ONE, 11 (2), 2016--1932-6203 |
| Availability: |
http://resolver.tudelft.nl/uuid:9b564797-2419-4fc7-b7fc-a488125e73e4 |
| Rights: |
© 2016 The Author(s) ; This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
| Accession Number: |
edsbas.C2B8E001 |
| Database: |
BASE |