Autophagy in major human diseases
| Title: | Autophagy in major human diseases |
|---|---|
| Authors: | Klionsky D. J.; Petroni G.; Amaravadi R. K.; Baehrecke E. H.; Ballabio A.; Boya P.; Bravo-San Pedro J. M.; Cadwell K.; Cecconi F.; Choi A. M. K.; Choi M. E.; Chu C. T.; Codogno P.; Colombo M.; Cuervo A. M.; Deretic V.; Dikic I.; Elazar Z.; Eskelinen E. -L.; Fimia G. M.; Gewirtz D. A.; Green D. R.; Hansen M.; Jaattela M.; Johansen T.; Juhasz G.; Karantza V.; Kraft C.; Kroemer G.; Ktistakis N. T.; Kumar S.; Lopez-Otin C.; Macleod K. F.; Madeo F.; Martinez J.; Melendez A.; Mizushima N.; Munz C.; Penninger J. M.; Perera R.; Piacentini M.; Reggiori F.; Rubinsztein D. C.; Ryan K.; Sadoshima J.; Santambrogio L.; Scorrano L.; Simon H. -U.; Simon A. K.; Simonsen A.; Stolz A.; Tavernarakis N.; Tooze S. A.; Yoshimori T.; Yuan J.; Yue Z.; Zhong Q.; Galluzzi L.; Pietrocola F. |
| Contributors: | Klionsky, D. J.; Petroni, G.; Amaravadi, R. K.; Baehrecke, E. H.; Ballabio, A.; Boya, P.; Bravo-San Pedro, J. M.; Cadwell, K.; Cecconi, F.; Choi, A. M. K.; Choi, M. E.; Chu, C. T.; Codogno, P.; Colombo, M.; Cuervo, A. M.; Deretic, V.; Dikic, I.; Elazar, Z.; Eskelinen, E. -L.; Fimia, G. M.; Gewirtz, D. A.; Green, D. R.; Hansen, M.; Jaattela, M.; Johansen, T.; Juhasz, G.; Karantza, V.; Kraft, C.; Kroemer, G.; Ktistakis, N. T.; Kumar, S.; Lopez-Otin, C.; Macleod, K. F.; Madeo, F.; Martinez, J.; Melendez, A.; Mizushima, N.; Munz, C.; Penninger, J. M.; Perera, R.; Piacentini, M.; Reggiori, F.; Rubinsztein, D. C.; Ryan, K.; Sadoshima, J.; Santambrogio, L.; Scorrano, L.; Simon, H. -U.; Simon, A. K.; Simonsen, A.; Stolz, A.; Tavernarakis, N.; Tooze, S. A.; Yoshimori, T.; Yuan, J.; Yue, Z.; Zhong, Q.; Galluzzi, L.; Pietrocola, F. |
| Publisher Information: | John Wiley and Sons Inc |
| Publication Year: | 2021 |
| Collection: | Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: | aging; cancer; inflammation; metabolic syndrome; neurodegeneration |
| Description: | Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34459017; info:eu-repo/semantics/altIdentifier/wos/WOS:000690861700001; volume:40; issue:19; numberofpages:64; journal:EMBO JOURNAL; http://hdl.handle.net/11573/1572497 |
| DOI: | 10.15252/embj.2021108863 |
| Availability: | http://hdl.handle.net/11573/1572497; https://doi.org/10.15252/embj.2021108863 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.C2C7C03E |
| Database: | BASE |