| Title: |
Introducing a New Polymerase Chain Reaction Panel–Based Cerebrospinal Fluid Evaluation for Encephalitis and Meningitis: Does It Influence Empiric Treatment Duration, Length of Hospital Stay, and Pathogen-Specific Diagnoses? |
| Authors: |
Sidler, Fabian; Bittel, Pascal; Marschall, Jonas; Jent, Philipp |
| Source: |
Open Forum Infectious Diseases ; volume 12, issue 5 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
We analyzed the impact of a diagnostic meningitis/encephalitis polymerase chain reaction panel. Introducing the test resulted in no significantly shortened empiric antibiotic streptococcal/meningococcal treatment (−1 day [95% confidence interval {CI}, 0–3 days]; P = .16), nor hospitalization (−2 days [95% CI, 0–3 days]; P = .86). Empiric treatment duration against Herpesviridae and Listeria monocytogenes remained unchanged, and pathogen-specific diagnoses were not increased. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf241 |
| DOI: |
10.1093/ofid/ofaf241/62999571/ofaf241.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaf241; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaf241/62999571/ofaf241.pdf; https://academic.oup.com/ofid/article-pdf/12/5/ofaf241/63273783/ofaf241.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.C2CD918 |
| Database: |
BASE |