| Title: |
Etiology of white matter hyperintensities in autosomal dominant and sporadic Alzheimer disease |
| Authors: |
Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Salloway, Stephen P.; Perrin, Richard J.; McDade, Eric; Levin, Johannes; Cruchaga, Carlos; Allegri, Ricardo F.; Fox, Nick C.; Goate, Alison; Day, Gregory S.; Koeppe, Robert A.; Chui, Helena C.; Berman, Sarah; Mori, Hiroshi; Sanchez-Valle, Raquel; Lee, Jae-Hong; Rosa-Neto, Pedro; Ruthirakuhan, Myuri; Wu, Che-Yuan; Swardfager, Walter; Benzinger, Tammie L. S.; Sohrabi, Hamid; Martins, Ralph N.; Bateman, Randall J.; Johnson, Keith A.; Sperling, Reisa A.; Greenberg, Steven M.; Schultz, Aaron P.; Chhatwal, Jasmeer P.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Shaw, Leslie M.; Khachaturian, Zaven; Carrillo, Maria; Potter, William; Barnes, Lisa; Bernard, Marie; González, Hector; Ho, Carole; Hsiao, John; Jackson, Jonathan; Masliah, Eliezer; Masterman, Donna; Okonkwo, Ozioma; Ryan, Laurie; Silverberg, Nina; Fleisher, Adam; Sacrey, Diana Truran; Fockler, Juliet; Conti, Cat; Veitch, Dallas; Neuhaus, John; Jin, Chengshi; Nosheny, Rachel; Ashford, Miriam; Flenniken, Derek; Kormos, Adrienne; Montine, Tom; Rafii, Michael; Raman, Rema; Jimenez, Gustavo; Donohue, Michael; Gessert, Devon; Salazar, Jennifer; Zimmerman, Caileigh; Cabrera, Yuliana; Walter, Sarah; Miller, Garrett; Coker, Godfrey; Clanton, Taylor; Hergesheimer, Lindsey; Smith, Stephanie; Adegoke, Olusegun; Mahboubi, Payam; Moore, Shelley; Pizzola, Jeremy; Shaffer, Elizabeth; Sloan, Brittany; Harvey, Danielle; Forghanian-Arani, Arvin; Borowski, Bret; Ward, Chad; Schwarz, Christopher; Jones, David; Gunter, Jeff; Senjem, Matthew; Vemuri, Prashanthi; Reid, Robert; Malone, Ian; Thompson, Paul; Thomopoulos, Sophia I.; Nir, Talia M.; Jahanshad, Neda; DeCArli, Charles; Knaack, Alexander; Fletcher, Evan; Tosun-Turgut, Duygu; Chen, Stephanie Rossi; Choe, Mark; Crawford, Karen; Yushkevich, Paul A.; Das, Sandhitsu; Reiman, Eric M.; Chen, Kewei; Mathis, Chet; Landau, Susan; Cairns, Nigel J.; Householder, Erin; Franklin, Erin E.; Bernhardt, Haley; Taylor-Reinwald, Lisa; Korecka, Magdalena; Figurski, Michael; Neu, Scott; Nho, Kwangsik; Risacher, Shannon L.; Apostolova, Liana; Shen, Li; Foroud, Tatiana M.; Nudelman, Kelly N.; Faber, Kelley; Wilmes, Kristi; Thal, Leon; Silbert, Lisa C.; Lind, Betty; Crissey, Rachel; Kaye, Jeffrey A.; Carter, Raina; Dolen, Sara; Quinn, Joseph; Schneider, Lon S.; Pawluczyk, Sonia; Becerra, Mauricio; Teodoro, Liberty; Dagerman, Karen; Spann, Bryan M.; Brewer, James; Vanderswag, Helen; Ziolkowski, Jaimie; Heidebrink, Judith L.; Zbizek-Nulph, Lisa; Lord, Joanne L.; Mason, Sara S.; Albers, Colleen S.; Knopman, David; Johnson, Kris; Villaneuva-Meyer, Javier; Pavlik, Valory; Pacini, Nathaniel; Lamb, Ashley; Kass, Joseph S.; Doody, Rachelle S.; Shibley, Victoria; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; Honig, Lawrence S.; Mintz, Akiva; Ances, Beau; Winkfield, David; Carroll, Maria; Stobbs-Cucchi, Georgia; Oliver, Angela; Creech, Mary L.; Mintun, Mark A.; Schneider, Stacy; Geldmacher, David; Love, Marissa Natelson; Griffith, Randall; Clark, David; Brockington, John; Marson, Daniel; Grossman, Hillel; Goldstein, Martin A.; Greenberg, Jonathan; Mitsis, Effie; Shah, Raj C.; Lamar, Melissa; Samuels, Patricia; Duara, Ranjan; Greig-Custo, Maria T.; Rodriguez, Rosemarie; Albert, Marilyn; Onyike, Chiadi; Farrington, Leonie; Rudow, Scott; Brichko, Rottislav; Kielb, Stephanie; Smith, Amanda; Raj, Balebail Ashok; Fargher, Kristin; Sadowski, Martin; Wisniewski, Thomas; Shulman, Melanie; Faustin, Arline; Rao, Julia; Castro, Karen M.; Ulysse, Anaztasia; Chen, Shannon; Sheikh, Mohammed O.; Singleton-Garvin, Jamika; Doraiswamy, P.M.; Petrella, Jeffrey R.; James, Olga; Wong, Terence Z.; Borges-Neto, Salvador; Karlawish, Jason H.; Wolk, David A.; Vaishnavi, Sanjeev; Clark, Christopher M.; Arnold, Steven E.; Smith, Charles D.; Jicha, Gregory A.; El Khouli, Riham; Raslau, Flavius D.; Lopez, Oscar L.; Oakley, MaryAnn; Simpson, Donna M.; Porsteinsson, Anton P.; Martin, Kim; Kowalski, Nancy; Keltz, Melanie; Goldstein, Bonnie S.; Makino, Kelly M.; Ismail, M. Saleem; Brand, Connie; Thai, Gaby; Pierce, Aimee; Yanez, Beatriz; Sosa, Elizabeth; Witbracht, Megan; Kelley, Brendan; Nguyen, Trung; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Lah, James J.; Hajjar, Ihab; Cellar, Janet S.; Burns, Jeffrey M.; Swerdlow, Russell H.; Brooks, William M.; Silverman, Daniel H. S.; Kremen, Sarah; Tingus, Kathleen; Lu, Po H.; Bartzokis, George; Woo, Ellen; Teng, Edmond; Graff-Radford, Neill R.; Parfitt, Francine; Poki-Walker, Kim; Farlow, Martin; Hake, Ann Marie; Matthews, Brandy R.; Brosch, Jared R.; Herring, Scott; van Dyck, Christopher H.; Mecca, Adam P.; Good, Susan P.; MacAvoy, Martha G.; Carson, Richard E.; Varma, Pradeep; Chertkow, Howard; Vaitekunis, Susan; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Heyn, Chris (Chinthaka); Hsiung, Ging-Yuek Robin; Kim, Ellen; Mudge, Benita; Sossi, Vesna; Feldman, Howard; Assaly, Michele; Finger, Elizabeth; Pasternak, Stephen; Rachinsky, Irina; Kertesz, Andrew; Drost, Dick; Rogers, John; Grant, Ian; Muse, Brittanie; Rogalski, Emily; Robson, Jordan; Mesulam, M.-Marsel; Kerwin, Diana; Wu, Chuang-Kuo; Johnson, Nancy; Lipowski, Kristine; Weintraub, Sandra; Bonakdarpour, Borna; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; Rosen, Howard; Miller, Bruce L.; Perry, David; Turner, Raymond Scott; Johnson, Kathleen; Reynolds, Brigid; MCCann, Kelly; Poe, Jessica; Marshall, Gad A.; Yesavage, Jerome A.; Taylor, Joy L.; Chao, Steven; Coleman, Jaila; White, Jessica D.; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Belden, Christine M.; Atri, Alireza; Clark, Kelly A.; Zamrini, Edward; Sabbagh, Marwan N.; Killiany, Ronald; Stern, Robert; Mez, Jesse; Kowall, Neil; Budson, Andrew E.; Obisesan, Thomas O.; Ntekim, Oyonumo E.; Wolday, Saba; Khan, Javed I.; Nwulia, Evaristus; Nadarajah, Sheeba; Lerner, Alan; Ogrocki, Paula; Tatsuoka, Curtis; Fatica, Parianne; Maillard, Pauline; Olichney, John; Carmichael, Owen; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Borrie, Michael; Lee, T-Y; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia M.; Perrin, Allison; Burke, Anna; Scharre, Douglas W.; Kataki, Maria; Tarawneh, Rawan; Hart, David; Zimmerman, Earl A.; Celmins, Dzintra; Miller, Delwyn D.; Boles Ponto, Laura L.; Smith, Karen Ekstam; Koleva, Hristina; Shim, Hyungsub; Nam, Ki Won; Schtulz, Susan K.; Williamson, Jeff D.; Craft, Suzanne; Cleveland, Jo; Yang, Mia; Sink, Kaycee M.; Ott, Brian R.; Drake, Jonathan; Tremont, Geoffrey; Daiello, Lori A.; Ritter, Aaron; Bernick, Charles; Munic, Donna; O'Connell, Abigail; Mintzer, Jacobo; Wiliams, Arthur; Masdeu, Joseph; Shi, Jiong; Garcia, Angelica; Newhouse, Paul; Potkin, Steven; Salloway, Steven; Malloy, Paul; Correia, Stephen; Kittur, Smita; Pearlson, Godfrey D.; Blank, Karen; Anderson, Karen; Flashman, Laura A.; Seltzer, Marc; Hynes, Mary L.; Santulli, Robert B.; Relkin, Norman; Chiang, Gloria; Lee, Athena; Lin, Michael; Ravdin, Lisa; Sood, Ajay; Blanchard, Kimberly S.; Fleischman, Debra; Arfanakis, Konstantinos; Varon, Daniel; Greig, Maria T.; Goldstein, Bonnie; Martin, Kimberly S.; Reist, Christopher; Sadowsky, Carl; Martinez, Walter; Villena, Teresa; Marshall, Gad; Peskind, Elaine R.; Petrie, Eric C.; Li, Gail; Noble, James M.; Voglein, Jonathan; Chrem Mendez, Patricio; Surace, Ezequiel; Ikonomovic, Snezana; Nadkarni, Neelesh K.; Lopera, Francisco; Ramirez, Laura; Aguillon, David; Leon, Yudy; Ramos, Claudia; Alzate, Diana; Baena, Ana; Londono, Natalia; Moreno, Sonia; Laske, Christoph; Kuder-Buletta, Elke; Graber-Sultan, Susanne; Preische, Oliver; Hofmann, Anna; Ikeuchi, Takeshi; Kasuga, Kensaku; Niimi, Yoshiki; Ishii, Kenji; Senda, Michio; Cash, Dave; Roh, Jee Hoon; Riddle, Meghan C.; Menard, William; Bodge, Courtney; Surti, Mustafa; Takada, Leonel Tadao; Sanchez-Gonzalez, V J; Orozco-Barajas, Maribel; Renton, Alan E.; Esposito, Bianca T.; Marsh, Jacob; Fernanadez, Victoria; Jerome, Gina; Herries, Elizabeth; Llibre-Guerra, Jorge; Johnson, Erik C.B.; Seyfried, Nicholas T.; Brooks, William S.; Bechara, Jacob A; Chen, Allison; Chen, Charles; Flores, Shaney; Hantler, Nancy; Hornbeck, Russ; Jarman, Steve; Keefe, Sarah; Koudelis, Deborah; Massoumzadeh, Parinaz; McCullough, Austin; McKay, Nicole; Nicklaus, Joyce; Pulizos, Christine; Wang, Qing; Mishall, Sheetal; Sabaredzovic, Edita; Deng, Emily; Candela, Madison; Smith, Hunter; Hobbs, Diana; Scott, Jalen; Wang, Peter; Xu, Xiong; Li, Yan; Gremminger, Emily; Ma, Yinjiao; Bui, Ryan; Lu, Ruijin; Martins, Ralph; Sosa Ortiz, Ana Luisa; Daniels, Alisha; Courtney, Laura; Supnet-Bell, PhD (CSB), Charlene; Xu, Jinbin; Ringman, John; Barthelemy, Nicolas; Smith, Jennifer |
| Publisher Information: |
American Medical Association |
| Publication Year: |
2023 |
| Description: |
Importance ; Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. ; Objective ; To estimate the associations of neurodegeneration and parenchymal and vessel amyloidosis with WMH accumulation and investigate whether systemic vascular risk is associated with WMH beyond these AD-intrinsic processes. ; Design, Setting, and Participants ; This cohort study used data from 3 longitudinal cohort studies conducted in tertiary and community-based medical centers—the Dominantly Inherited Alzheimer Network (DIAN; February 2010 to March 2020), the Alzheimer’s Disease Neuroimaging Initiative (ADNI; July 2007 to September 2021), and the Harvard Aging Brain Study (HABS; September 2010 to December 2019). ; Main Outcome and Measures ; The main outcomes were the independent associations of neurodegeneration (decreases in gray matter volume), parenchymal amyloidosis (assessed by amyloid positron emission tomography), and vessel amyloidosis (evidenced by cerebral microbleeds [CMBs]) with cross-sectional and longitudinal WMH. ; Results ; Data from 3960 MRI sessions among 1141 participants were included: 252 pathogenic variant carriers from DIAN (mean [SD] age, 38.4 [11.2] years; 137 [54%] female), 571 older adults from ADNI (mean [SD] age, 72.8 [7.3] years; 274 [48%] female), and 318 older adults from HABS (mean [SD] age, 72.4 [7.6] years; 194 [61%] female). Longitudinal increases in WMH volume were greater in individuals with CMBs compared with those without (DIAN: t = 3.2 [P = .001]; ADNI: t = 2.7 [P = .008]), associated with longitudinal decreases in gray matter volume (DIAN: t = −3.1 [P = .002]; ADNI: t = −5.6 [P < .001]; HABS: t = −2.2 [P = .03]), greater in older individuals (DIAN: t = 6.8 [P < .001]; ADNI: t = 9.1 [P ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
ispartof: JAMA Neurology spage 1353 epage 1363 issue 12 vol 80; 991005609666607891; alma:61MUN_INST/bibs/991005609666607891 |
| DOI: |
10.1001/jamaneurol.2023.3618 |
| Availability: |
https://doi.org/10.1001/jamaneurol.2023.3618; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Etiology-of-white-matter-hyperintensities-in/991005609666607891 |
| Rights: |
© 2023 American Medical Association. |
| Accession Number: |
edsbas.C2D9861D |
| Database: |
BASE |