| Title: |
Susceptibility and resistance to 6‐sulfanilamidoindazole‐induced arthritis among inbred strains of rats |
| Authors: |
Samuelson, Cecil O.; Griffiths, Marie M.; Mathews, Jeffrey L.; Clegg, Daniel O.; Ward, John R. |
| Source: |
Arthritis & Rheumatism ; volume 27, issue 6, page 689-693 ; ISSN 0004-3591 1529-0131 |
| Publisher Information: |
Wiley |
| Publication Year: |
1984 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Inflammation induced by 6‐sulfanilamidoindazole (6‐SAI) in aged, outbred rats is predictably produced, but the pathogenesis is not understood. We demonstrate the variable resistance of 15 inbred rat strains to 6‐SAI arthritis. Susceptibility to 6‐SAI arthritis is not directly linked to the major histocompatibility complex, although resistance is related to the major histocompatibility complex in other experimental forms of rat arthritis. The genetic background of these inbred rat strains appears to have a major role in 6‐SAI arthritis susceptibility. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/art.1780270613 |
| Availability: |
https://doi.org/10.1002/art.1780270613; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fart.1780270613; https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780270613 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.C3257F5C |
| Database: |
BASE |