| Title: |
Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers |
| Authors: |
Matemo, D; Kinuthia, J; John, F; Chung, M; Farquhar, C; John-Stewart, G; Kiarie, J |
| Source: |
International Journal of STD & AIDS ; volume 20, issue 11, page 790-792 ; ISSN 0956-4624 1758-1052 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2009 |
| Description: |
The sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a study to determine the prevalence and correlates of false-positive Abbott Determine™ and false-negative Uni-Gold™ rapid HIV-1 test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1 using Abbott Determine™ and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were re-tested by Uni-Gold™. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples that had positive Abbott Determine™ and negative Uni-Gold™. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were tested antenatally and 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott Determine™ and on retesting with Uni-Gold™ 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher in antenatal women than in postnatal women (2% versus 1%, P = 0.03). In conclusion, indeterminate rapid HIV-1 test results are more common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal programmes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1258/ijsa.2008.008427 |
| Availability: |
https://doi.org/10.1258/ijsa.2008.008427; https://journals.sagepub.com/doi/pdf/10.1258/ijsa.2008.008427; https://journals.sagepub.com/doi/full-xml/10.1258/ijsa.2008.008427 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.C32C0056 |
| Database: |
BASE |