| Title: |
Additional file 1 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
| Authors: |
Lin, Benjamin; Shelton, Abigail K; Smithberger, Erin; Ziebro, Julia; Skinner, Kasey R; Bash, Ryan E; Kirkman, Richard; Stamper, Allie; Butler, Madison; Flores, Alex; Angus, Steven P; East, Michael P; Cloughesy, Timothy F; Nathanson, David A; Berens, Michael E; Sarkaria, Jann N; Binder, Zev A; O’Rourke, Donald M; Howton, Timothy C; Lasseigne, Brittany N; Willey, Christopher D; Johnson, Gary L; Hjelmeland, Anita B; Furnari, Frank B; Miller, C Ryan |
| Source: |
Research Data Catalog |
| Publisher Information: |
UAB Digital Commons |
| Publication Year: |
2025 |
| Subject Terms: |
Biochemistry; Medicine; Genetics; FOS: Biological sciences; Pharmacology; Biotechnology; Chemical Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Marine Biology; Cancer; Hematology; Virology; Computational Biology |
| Description: |
Supplementary Material 1: Table ST.1 Genes in upset plot (Fig. 3A) of FS culture of acquired resistant cell lines. Table ST.2 Genes in upset plot (Fig. 3B) of SS culture of acquired resistant cell lines. Table ST.3 Genes in upset plot (Fig. 3C) of unique kinases identified in upset plots from Fig. 3A, B. Table ST.4 Genes in upset plot (Fig. 3D) of shared kinases identified in upset plots from Fig. 3AB. Table ST.5 BL kinase signatures identified in cells with acquired resistance. Table ST.6 Genes in upset plot (Fig. 5C) of upregulated kinases after afatinib treatment. Table ST.7. Genes in upset plot (Fig. 5D) of downregulated kinases after afatinib treatment. Table ST.8 EGFRi signature from DE kinases identified in acutely treated CEv3 and acquired resistance cells. Table ST. 9 Genes in upset plot (Fig. 5E) of BL kinase and EGFRi signatures. |
| Document Type: |
text |
| Language: |
unknown |
| Relation: |
https://digitalcommons.library.uab.edu/datasets/273; https://doi.org/10.6084/m9.figshare.29431960 |
| DOI: |
10.6084/m9.figshare.29431960 |
| Availability: |
https://digitalcommons.library.uab.edu/datasets/273; https://doi.org/10.6084/m9.figshare.29431960 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.C362C86E |
| Database: |
BASE |