| Title: |
Circulating hsa-miR-5096 predicts 18F-FDG PET/CT positivity and modulates somatostatin receptor 2 expression: a novel miR-based assay for pancreatic neuroendocrine tumors |
| Authors: |
Bocchini, Martine; Tazzari, Marcella; Ravaioli, Sara; Piccinini, Filippo; Foca, Flavia; Tebaldi, Michela; Nicolini, Fabio; Grassi, Ilaria; Severi, Stefano; Calogero, Raffaele Adolfo; Arigoni, Maddalena; Schrader, Joerg; Mazza, Massimiliano; Paganelli, Giovanni |
| Contributors: |
Bocchini, Martine; Tazzari, Marcella; Ravaioli, Sara; Piccinini, Filippo; Foca, Flavia; Tebaldi, Michela; Nicolini, Fabio; Grassi, Ilaria; Severi, Stefano; Calogero, Raffaele Adolfo; Arigoni, Maddalena; Schrader, Joerg; Mazza, Massimiliano; Paganelli, Giovanni |
| Publication Year: |
2023 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
pancreatic neuroendocrine tumors; PRRT (peptide receptor radionuclide therapy); miRNA – microRNA; functional imaging (positron-emission tomography); SSTR2 |
| Description: |
Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are rare diseases encompassing pancreatic (PanNETs) and ileal NETs (SINETs), characterized by heterogeneous somatostatin receptors (SSTRs) expression. Treatments for inoperable GEP-NETs are limited, and SSTR-targeted Peptide Receptor Radionuclide Therapy (PRRT) achieves variable responses. Prognostic biomarkers for the management of GEP-NET patients are required. 18F-FDG uptake is a prognostic indicator of aggressiveness in GEP-NETs. This study aims to identify circulating and measurable prognostic miRNAs associated with 18FFDG- PET/CT status, higher risk and lower response to PRRT. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37287922; info:eu-repo/semantics/altIdentifier/wos/WOS:001000928100001; volume:13; firstpage:1; lastpage:18; numberofpages:18; journal:FRONTIERS IN ONCOLOGY; https://hdl.handle.net/11585/926500; https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1136331/full |
| DOI: |
10.3389/fonc.2023.1136331 |
| DOI: |
10.3389/fonc.2023.1136331/full |
| Availability: |
https://hdl.handle.net/11585/926500; https://doi.org/10.3389/fonc.2023.1136331; https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1136331/full |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C3683333 |
| Database: |
BASE |