| Title: |
DNA methylation in peripheral tissues and left-handedness |
| Authors: |
Odintsova, Veronika V.; Suderman, Matthew; Hagenbeek, Fiona A.; Caramaschi, Doretta; Hottenga, Jouke-Jan; Pool, René; Heijmans, Bastiaan T.; ’t Hoen, Peter A. C.; van Meurs, Joyce; Isaacs, Aaron; Jansen, Rick; Franke, Lude; Boomsma, Dorret I.; van Dongen, Jenny; Hottenga, Jouke J.; van Greevenbroek, Marleen M. J.; Stehouwer, Coen D. A.; van der Kallen, Carla J. H.; Schalkwijk, Casper G.; Wijmenga, Cisca; Zhernakova, Sasha; Tigchelaar, Ettje F.; Slagboom, P. Eline; Beekman, Marian; Deelen, Joris; van Heemst, Diana; Veldink, Jan H.; Van den Berg, Leonard H.; van Duijn, Cornelia M.; Hofman, Bert A.; Uitterlinden, André G.; Jhamai, P. Mila; Verbiest, Michael; Suchiman, H. Eka D.; Verkerk, Marijn; van der Breggen, Ruud; van Rooij, Jeroen; Lakenberg, Nico; Mei, Hailiang; van Iterson, Maarten; van Galen, Michiel; Bot, Jan; Zhernakova, Dasha V.; ’t Hof, Peter van; Deelen, Patrick |
| Contributors: |
Amsterdam Public Health Institute Methodology travel grant; The UK Medical Research Council and Wellcome; BBSRC; MRC; Seventh Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; 23andMe; National Health and Medical Research Council; KNAW Academy Professor Award; NWO Large Scale infrastructures, X-omics |
| Source: |
Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2022 |
| Description: |
Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites ( P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children ( N = 1737), we observed moderately stable associations across age (correlation range [0.355–0.578]), but inconsistent across tissues (correlation range [− 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41598-022-08998-0 |
| Availability: |
https://doi.org/10.1038/s41598-022-08998-0; https://www.nature.com/articles/s41598-022-08998-0.pdf; https://www.nature.com/articles/s41598-022-08998-0 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.C3B03297 |
| Database: |
BASE |