| Title: |
Veterinary cancer epidemiology: using canine spontaneous tumor models for the study of human cancers |
| Authors: |
Ruple-Czerniak, Audrey, author; Morley, Paul S., advisor; Hungerford, Laura L., committee member; Nelson-Ceschin, Tracy L., committee member; Page, Rodney L., committee member |
| Publisher Information: |
Colorado State University. Libraries |
| Publication Year: |
2007 |
| Collection: |
Digital Collections of Colorado (Colorado State University) |
| Subject Terms: |
histiocytic sarcoma; translational; public health; cancer; epidemiology; lymphoma |
| Description: |
2014 Fall. ; Includes bibliographical references. ; Cancer is the second leading cause of death in humans worldwide and the most common cause of death for humans in developed countries. Cancer is also the leading cause of mortality in dogs. Animal models, primarily genetically engineered mice, have been used historically in research aimed at discovering causes and treatments for human cancer types, but the canine model has been underutilized in this research area. Though the field of canine cancer epidemiology is relatively new, it has great potential to produce answers to research questions pertaining to cancer prevention, development, and treatment relevant to both dogs and humans. In fact, the canine spontaneous tumor model is actually a better model for use in human cancer epidemiology research than other animal models or even human populations. This is due to the fact that dogs spontaneously produce many different types of tumors that are molecularly indistinguishable from human tumors. Canine DNA shares a large amount of ancestral sequence with human DNA, but dogs have greater genetic homogeneity - even across breeds - than do humans, which simplifies disease mapping at the genomic level. Dogs live in the same environments as humans, too, so they share many similar exposures to environmental factors that may contribute to the development of cancer. Tumors in dogs progress at a rapid rate as compared to humans and many tumor types that are rare in humans occur frequently in dogs. These facts, when considered along with the existence of an accelerated aging process in dog, support how use of the canine spontaneous tumor model will allow us to gain a greater understanding of genetic and environmental contributions to human disease and do so at a rapid pace. The primary aims of my dissertation were to examine the current body of evidence produced through canine cancer epidemiology research, produce new research using study designs similar to those used in human cancer epidemiology research, and show how we can ... |
| Document Type: |
text |
| File Description: |
born digital; doctoral dissertations; application/pdf |
| Language: |
English |
| Relation: |
RupleCzerniak_colostate_0053A_12697.pdf; http://hdl.handle.net/10217/88535 |
| Availability: |
http://hdl.handle.net/10217/88535 |
| Rights: |
Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. |
| Accession Number: |
edsbas.C3D0481B |
| Database: |
BASE |