| Title: |
TM1-5 Optimising observation strategies for incidentally discovered intracranial meningiomas |
| Authors: |
Islim, AI; Mohan, M; Moon, RDC; Mills, SJ; Brodbelt, AR; Haylock, BJ; Rathi, N; Kolamunnage-Dona, R; Jenkinson, MD |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2019 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts for JNNP |
| Description: |
Objectives Develop a model to identify incidental meningiomas at risk of observation failure. Design Retrospective study (2007–2015). Subjects 385 patients. Mean age 62.6 years. Methods Observation failure was defined as: new symptoms, MRI progression (absolute growth rate 2 cm3/year or absolute growth rate 1 cm3/year +relative growth rate 30%/year) or loss of treatment options. A prognostic model was developed using MRI and patient comorbidity. Results Over a median of 36 months, 44 (10.9%) meningiomas failed observation. Median time to failure was 33 months. Model parameters were based on statistical and clinical considerations and included: increasing tumour size (HR=2.17 [95% CI=1.53–3.09], p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://jnnp.bmj.com/cgi/content/short/90/3/e9-c; http://dx.doi.org/10.1136/jnnp-2019-ABN.29 |
| DOI: |
10.1136/jnnp-2019-ABN.29 |
| Availability: |
http://jnnp.bmj.com/cgi/content/short/90/3/e9-c; https://doi.org/10.1136/jnnp-2019-ABN.29 |
| Rights: |
Copyright (C) 2019, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.C3D7202 |
| Database: |
BASE |