| Title: |
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report |
| Authors: |
Dominguez-Valentin, M; Crosbie, EJ; Engel, C; Aretz, S; Macrae, F; Winship, I; Capella, G; Thomas, H; Nakken, S; Hovig, E; Nielsen, M; Sijmons, RH; Bertario, L; Bonanni, B; Tibiletti, MG; Cavestro, GM; Mints, M; Gluck, N; Katz, L; Heinimann, K; Vaccaro, CA; Green, K; Lalloo, F; Hill, J; Schmiegel, W; Vangala, D; Perne, C; Strauß, HG; Tecklenburg, J; Holinski-Feder, E; Steinke-Lange, V; Mecklin, JP; Plazzer, JP; Pineda, M; Navarro, M; Vidal, JB; Kariv, R; Rosner, G; Piñero, TA; Gonzalez, ML; Kalfayan, P; Ryan, N; ten Broeke, SW; Jenkins, MA; Sunde, L; Bernstein, I; Burn, J; Greenblatt, M; de Vos tot Nederveen Cappel, WH; Della Valle, A; Lopez-Koestner, F; Alvarez, K; Büttner, R; Görgens, H; Morak, M; Holzapfel, S; Hüneburg, R; von Knebel Doeberitz, M; Loeffler, M; Rahner, N; Weitz, J; Pylvänäinen, K; Renkonen-Sinisalo, L; Lepistö, A; Auranen, A; Hopper, JL; Win, AK; Haile, RW; Lindor, NM; Gallinger, S; Le Marchand, L; Newcomb, PA; Figueiredo, JC; Thibodeau, SN; Therkildsen, C; Okkels, H; Ketabi, Z; Denton, OG; Rødland, EA; Vasen, H; Neffa, F; Esperon, P; Tjandra, D; Möslein, G; Sampson, JR; Evans, DG; Seppälä, TT; Møller, P |
| Publisher Information: |
ELSEVIER SCIENCE INC |
| Publication Year: |
2021 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
PURPOSE: To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. METHODS: The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. RESULTS: Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. CONCLUSION: Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1098-3600 |
| Relation: |
https://hdl.handle.net/11343/274252 |
| Availability: |
https://hdl.handle.net/11343/274252 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.C3DF0D09 |
| Database: |
BASE |