| Title: |
Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22 + Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia |
| Authors: |
Chevallier, Patrice; Leguay, Thibaut; Delord, Marc; Salek, Cyril; Kim, Rathana; Huguet, Françoise; Hicheri, Yosr; Wartiovaara-Kautto, Ulla; Raffoux, Emmanuel; Cluzeau, Thomas; Balsat, Marie; Roth-Guepin, Gabrielle; Tavernier, Emmanuelle; Lepretre, Stephane; Bilger, Karin; Bergugnat, Hugo; Berceanu, Ana; Alexis, Magda; Doubek, Michael; Brissot, Eolia; Hunault-Berger, Mathilde; Lebon, Delphine; Turlure, Pascal; Chantepie, Sylvain; Belhabri, Amine; Wickenhauser, Stefan; Bastie, Jean-Noel; Cacheux, Victoria; Himberlin, Chantal; Banos, Anne; Gardin, Claude; Bonnet, Sarah; Plantier, Isabelle; Pica, Gian Matteo; Escoffre-Barbe, Martine; Boissel, Nicolas; Dombret, Herve; Clappier, Emmanuelle; Rousselot, Philippe; Charbonnier, Amandine; Assouan, Deborah; Hubert, Amandine; Quint, Marine; Kossi, Fulvia Guenbem; Deruche, Elodie; Hunault, Mathilde; Marie, Céline; Robin, Jean-Baptiste; Gay, Julie; Capdupuy, Claudie; Labarrere, Sévérine; Vincent, Edith; Simonet-Boissard, Marion; Larosa, Fabrice; Desbrosses, Yohan; Boiteux, Guillaume; Dufour, Vinciane; Tissot, Elise; Braun, Thorsten; Gardin, Pr Claude; Vidal, Valérie; Edouart, Geoffrey; Vilque, Jean-Pierre; Johnson Ansah, Hyacinthe; Lebouvier, Angélique; Zapalovicz, Marie Charlotte; Renault, Léa; Gian Matteo, Pica; Courouau, Alix; Prieur, Fabienne; Dupre, Charlene; de Renzis, Benoit; Chaleteix, Carine; Fayard, Amandine; Roy, Gwendoline; Bastie, Jean-Noël; Caillot, Denis; Devaux, Laetitia; Lebourgeois, Amandine; Bonnet, Antoine; Peterlin, Pierre; Lok, Anne; Guilllaume, Thierry; Fontaine, Alexis Morice; Touati, Mohamed; Kennel, Céline; Dmytruck, Natalya; Abraham, Julie; Jaccard, Arnaud; Remenieras, Liliane; Girault, Stéphane; Gourin, Marie Pierre; Penot, Amélie; Moreau, Stéphane; Philipon, Céline; Roche, Delphine; Gilis, Lila; Virelizier, Nicolas; Michalet, Anne-Sophie; Monfray, Jérémy; Thomas, Xavier; Praire, Aline; Guepin, Gabrielle Roth; Bonmati, Caroline; Moulin, Charline; Jacquet, Caroline; Carpodomi, Anne; Bouillet, Hélène; Carpentier, Odile; Montero, Mélanie; Pires, Aude; Gastaud, Lauris; Gama, Anastasia; Coelle, Céline; Karmout, Sonia; Loschi, Michael; Lechardeur, Jessica; Chokri, Hatroubi; Broussot, Loic; Waulthier, Agathe; Jourdan, Eric; Scherman, Elodie; Umuhire, Diane; Damiano, Maria Alessandra; Hicheri, Yors; Saillard, Colombe; d'Incan, Evelyne; Hospital, Marie-Anne; l'Attention, Jean Laurent; Rabah, Mme Nassima; Cesari, Laura Castillo; Gehlkopf, Eve; Vincent, Laure; Navarro, Robert; Quittet, Philippe; Fegueux, Nathalie; Ceballos, Patrice; Marin, Fanny Baguet; Sabadash, Véra; Ochmann, Marlène; Laboure, Nina Akakelyan; Bembrahmi, Omar; Michel, Olivier; Ouahrawi, Brahim; Legrand, Olivier; Vekhoff, Anne; Isnard, Françoise; Sa, Sara; Dombret, Hervé; Lenguine, Etienne; Rabian, Florence; Lebras, Karine Celli; Fauvaux, Catherine; Gros, François-Xavier; Cazaubiel, Titouan; Melot, Cyril; Dematteis, Valentin; Messina, Antonella; Le, Quoc-Hung; Maggi, Lucia; Barre, Martine Escoffre; Moignet, Aline; de Guibert, Sophie; Bernard, Marc; Decaux, Olivier; de la Chapelle, Thierry Lamy; Nimubona, Stanislas; Kadende, Mme Erica; Flavigny, Aloyse; Detourmignies, Laurence; Wemeau, Mathieu; Dervite, Isabelle; Dernivoix, Kathy; Camille, Mme; Denizart, Ingrid; Lepretre, Stéphane; Stamatoullas-Bastard, Aspasia; Fontoura, Marie-Laure; Jardin, Fabrice; Menard, Anne-Lise; Camus, Vincent; Lanic, Helene; Contentin, Nathalie; Cardinael, Nathalie; Lemasle-Hue, Emilie; Alani, Mustafa; Lebreton, Pierre; Atia, Youcef; Ledoux, Marie-Pierre; Sonntag, Cécile; Collin, Camille; Guyotat, Denis; Soglu, Gilbert; Le Jeune, Caroline; Cornillon, Jérôme; Durieux, Coralie; Lavoué, Céline; Miler, Dorante; Tavitian, Suzanne; Soldan, Justine; Rigaudeau, Sophie; Philippe, Laure; Lambert, Juliette; Besson, Caroline; Cabannes, Aurélie; Longval, Thomas; Taksin, Anne-Laure; Bah, Mariama; Beulaygue, Anaïs; Folber, Frantisek; Hrabovsky, Stepan; Brzonova, Jana; Vejsadova, Hana; Novotova, Elena; Mertova, Jolana; Salonen, Minna; Vaalas, Saara |
| Contributors: |
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Hôpital Haut-Lévêque CHU Bordeaux; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux); Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Institute of Hematology and Blood Transfusion; Génomes, biologie cellulaire et thérapeutiques (GenCellDis (U944 / UMR7212)); Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service Hématologie - IUCT-Oncopole CHU Toulouse; Pôle Biologie CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Institut Paoli-Calmettes (IPC); Fédération nationale des Centres de lutte contre le Cancer (FNCLCC); Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université Côte d'Azur (UniCA); Centre Hospitalier Universitaire de Nice (CHU Nice); Centre Hospitalier Lyon Sud CHU - HCL (CHLS); Hospices Civils de Lyon (HCL); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Institut de Cancérologie de la Loire Lucien Neuwirth; Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Service d'hématologie CRLCC Henri Becquerel; Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel); Hôpitaux Universitaires de Strasbourg (HUS); Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine; ex- Institut Universitaire Hématologie-IUH) (IRSL); Université Paris Cité (UPCité); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Centre Hospitalier Regional d'Orléans (CHRO); Masaryk University Brno = Masarykova univerzita Brno = Université Masaryk Brno (MU / MUNI); Central European Institute of Technology Brno (CEITEC MU); Brno University of Technology Brno (BUT); University Hospital Brno; Centre de Recherche Saint-Antoine (CRSA); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); CHU Amiens-Picardie; HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM); Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Source: |
ISSN: 0732-183X. |
| Publisher Information: |
CCSD; American Society of Clinical Oncology |
| Publication Year: |
2024 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology |
| Description: |
International audience ; PURPOSE The use of inotuzumab ozogamicin (InO), a conjugated anti-CD22 monoclonal antibody, is becoming a promising frontline treatment for older patients with ALL. PATIENTS AND METHODS EWALL-INO is an open-label prospective multicenter phase II trial (ClinicalTrials.gov identifier: NCT03249870 ). Patients age 55 years and older with newly diagnosed CD22 + Philadelphia chromosome–negative (Ph–) B-cell precursor (BCP) ALL were eligible. After a prephase, a first induction consisting of vincristine, dexamethasone, and three injections of InO (0.8 mg/m 2 day 1, 0.5 mg/m 2 day 8/day 15) was followed by a second induction combining cyclophosphamide, dexamethasone, and two injections of InO (0.5 mg/m 2 day 1/day 8). Responders received up to six cycles of chemotherapy consolidation and 18-month chemotherapy maintenance. Allotransplant was allowed after three consolidations. The primary end point was 1-year overall survival (OS). RESULTS Between December 2017 and March 2022, 131 patients (median age 68 years) were included. Three patients died during induction 1 (n = 130), two from multiple organ failure and one from hemorrhage, and none during induction 2 (n = 120). After induction 2, 90% of the patients achieved complete remission (CR) or CR with incomplete platelet recovery (CRp) and 80% had measurable residual disease (MRD2) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1200/JCO.24.00490 |
| Availability: |
https://u-picardie.hal.science/hal-04752518; https://doi.org/10.1200/JCO.24.00490 |
| Accession Number: |
edsbas.C4972501 |
| Database: |
BASE |