| Title: |
Small conductance Ca2+ activated K+ channels modulate synaptic plasticity and memory encoding |
| Authors: |
Robert W Stackman; Rebecca S Hammond; Eftihia Linardatos; Aaron Gerlach; James Maylie; John P Adelman; Thanos Tzounopoulos |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
http://www.dumay.info/pdf/Modulate/5.pdf. |
| Publication Year: |
2002 |
| Collection: |
CiteSeerX |
| Description: |
Activity-dependent changes in neuronal excitability and synaptic strength are thought to underlie memory encoding. In hippocampal CA1 neurons, small conductance Ca 2ϩ -activated K ϩ (SK) channels contribute to the afterhyperpolarization, affecting neuronal excitability. In the present study, we examined the effect of apamin-sensitive SK channels on the induction of hippocampal synaptic plasticity in response to a range of stimulation frequencies. In addition, the role of apamin-sensitive SK channels on hippocampal-dependent memory encoding and retention was also tested. The results show that blocking SK channels with apamin increased the excitability of hippocampal neurons and facilitated the induction of synaptic plasticity by shifting the modification threshold to lower frequencies. This facilitation was NMDA receptor (NMDAR) dependent and appeared to be postsynaptic. Mice treated with apamin demonstrated accelerated hippocampal-dependent spatial and nonspatial memory encoding. They required fewer trials to learn the location of a hidden platform in the Morris water maze and less time to encode object memory in an object-recognition task compared with saline-treated mice. Apamin did not influence long-term retention of spatial or nonspatial memory. These data support a role for SK channels in the modulation of hippocampal synaptic plasticity and hippocampal-dependent memory encoding. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1061.6304; http://www.dumay.info/pdf/Modulate/5.pdf |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1061.6304; http://www.dumay.info/pdf/Modulate/5.pdf |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.C4A641CC |
| Database: |
BASE |