| Title: |
Skin Barrier and Immune Response related Biomarkers of Solar UVR Exposure comparing Indoor and Outdoor Workers |
| Authors: |
de Boer, F.L.; van der Molen, H.F.; Wang, J.-H.; Raun, E.; Pereda, J.; Hwu, E.E.-T; Jakasa, I.; Dubrac, S.; Rustemeyer, T.; Kezic, S. |
| Source: |
de Boer , F L , van der Molen , H F , Wang , J-H , Raun , E , Pereda , J , Hwu , EE -T , Jakasa , I , Dubrac , S , Rustemeyer , T & Kezic , S 2024 , ' Skin Barrier and Immune Response related Biomarkers of Solar UVR Exposure comparing Indoor and Outdoor Workers ' , JID Innovations , vol. 4 , no. 3 , 100280 . https://doi.org/10.1016/j.xjidi.2024.100280 |
| Publication Year: |
2024 |
| Collection: |
Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| Subject Terms: |
Biomarkers; Occupational UVR exposure; Stratum corneum; UVR; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Outdoor workers have increased risk of developing keratinocyte cancer due to accumulated skin damage resulting from chronic and excessive exposure to ultraviolet radiation (UVR). This study aims to identify potential non-invasive biomarkers to assess chronic UVR exposure. We analysed stratum corneum (SC) biomarkers collected from two skin locations and two occupational groups with contrasting solar UVR exposure: the forehead and retro-auricular skin among outdoor (OW) and indoor workers (IW). Using a linear mixed model adjusting for age and skin phototype, we compared biomarkers between both skin sites in IW and OW. We measured markers of the immune response and skin barrier, including cytokines, growth factors, 15 Hydroxyeicosatetraenoic acid (15-HETE), cis- and trans urocanic acid (UCA) and corneocyte topography indicated by circular nano objects (CNO). Differences between the two skin sites were found for cis UCA, total UCA, IL-1 α, IL-1RA, IL-1RA/IL-1α, IL-18, 15-HETE, CCL4 and CNO. The levels of cUCA and CCL4 also differed between IW and OW. These findings underscore changes in both immune response and skin barrier induced by UVR. They indicate the potential utility of SC biomarkers in detecting both chronic UVR exposure in occupational setting and, aiding in the development of preventive measures. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| DOI: |
10.1016/j.xjidi.2024.100280 |
| Availability: |
https://orbit.dtu.dk/en/publications/2b4d2750-8588-4d64-8520-0dfdacdf7642; https://doi.org/10.1016/j.xjidi.2024.100280; https://backend.orbit.dtu.dk/ws/files/376739705/1-s2.0-S2667026724000274-main.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C4CE79D0 |
| Database: |
BASE |