| Title: |
The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life? |
| Authors: |
Kirilovsky, Amos; El Sissy, Carine; Zeitoun, Guy; Marliot, Florence; Haicheur, Nacilla; Lagorce-Pagès, Christine; Taieb, Julien; Karoui, Mehdi; Custers, Petra; Dizdarevic, Edina; Iseas, Soledad; Hansen, Torben, Frøstrup; Jensen, Lars, Henrik; Beets, Geerard; Gérard, Jean, Pierre; Castillo-Martin, Mireia; Figueiredo, Nuno; Habr-Gama, Angelita; Perez, Rodrigo; Galon, Jérôme; Pagès, Franck |
| Contributors: |
Immunologie et Cancérologie Intégratives = Integrative Cancer Immunology CRC; Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); Service d’anatomo‑pathologie AP-HP Hôpital Européen Georges Pompidou (Centre de Ressources biologiques); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); Université Paris Cité (UPCité); Netherlands Cancer Institute (NKI); Antoni van Leeuwenhoek Hospital; School for Oncology and Developmental Biology Maastricht (GROW); Maastricht University Maastricht -Maastricht University Medical Centre (MUMC); Maastricht University Maastricht; University of Southern Denmark = Syddansk Universitet (SDU); Hospital de Gastroenterología Bonorino Udaondo Buenos Aires; Centre de Lutte contre le Cancer Antoine Lacassagne Nice (UNICANCER/CAL); UNICANCER-Université Côte d'Azur (UniCA); Université Nice Sophia Antipolis (1965 - 2019) (UNS); Clinical Center Champalimaud Lisbon; Champalimaud Foundation |
| Source: |
ISSN: 1949-2553 ; Oncotarget ; https://hal.sorbonne-universite.fr/hal-03534276 ; Oncotarget, 2022, 13 (1), pp.18-31. ⟨10.18632/oncotarget.28100⟩. |
| Publisher Information: |
CCSD; Impact journals |
| Publication Year: |
2022 |
| Subject Terms: |
radiochemotherapy; prognosis; watch and wait; immunoscore; rectal cancer; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Because of the function and anatomical environment of the rectum, therapeutic strategies for local advanced rectal cancer (LARC) must deal with two challenging stressors that are a high-risk of local and distal recurrences and a high-risk of poor quality of life (QoL). Over the last three decades, advances in screening tests, therapies, and combined-modality treatment options and strategies have improved the prognosis of patients with LARC. However, owing to the heterogeneous nature of LARC and genetic status, the patient may not respond to a specific therapy and may be at increased risk of side-effects without the life-prolonging benefit. Indeed, each therapy can cause its own side-effects, which may worsen by a combination of treatments resulting in long-term poor QoL. In LARC, QoL has become even more essential with the increasing incidence of rectal cancer in young individuals. Herein, we analyzed the value of the Immunoscore-Biopsy (performed on tumor biopsy at diagnosis) in predicting outcomes, alone or in association with clinical and imaging data, for each therapy used in LARC. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35018217; PUBMED: 35018217; PUBMEDCENTRAL: PMC8734641 |
| DOI: |
10.18632/oncotarget.28100 |
| Availability: |
https://hal.sorbonne-universite.fr/hal-03534276; https://hal.sorbonne-universite.fr/hal-03534276v1/document; https://hal.sorbonne-universite.fr/hal-03534276v1/file/28100-1070424-1-PB.pdf; https://doi.org/10.18632/oncotarget.28100 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.C4D0D9D2 |
| Database: |
BASE |