| Title: |
Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients |
| Authors: |
Aiello E. N.; Solca F.; Torre S.; Gentile F.; Scheveger F.; Olivero M.; Colombo E.; Maranzano A.; Manzoni M.; Morelli C.; Doretti A.; Verde F.; Silani V.; Ticozzi N.; Poletti B. |
| Contributors: |
Aiello, E; Solca, F; Torre, S; Gentile, F; Scheveger, F; Olivero, M; Colombo, E; Maranzano, A; Manzoni, M; Morelli, C; Doretti, A; Verde, F; Silani, V; Ticozzi, N; Poletti, B |
| Publisher Information: |
Springer-Verlag Italia s.r.l.; IT |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Activities of daily living; Amyotrophic lateral sclerosi; Frontotemporal degeneration; Functional independence; Neuropsychology |
| Description: |
Background: The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 88 ALS patients without frontotemporal dementia were assessed for FI—Katz’s Basic ADL Scale (BADL) and Lawton-Brody’s Instrumental ADL Scale (IADL)—, cognition—Edinburgh Cognitive and Behavioural ALS Screen (ECAS)—and behaviour—Beaumont Behavioural Inventory and Dimensional Apathy Scale. The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders—i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King’s and Milano-Torino stages. Results: Higher scores on the ECAS-Language were associated with higher IADL scores (p = 0.005), whilst higher apathetic features—as measured by the Dimensional Apathy Scale (DAS)—were inversely related to the BADL (p = 0.003). Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores. Patients with abnormal ECAS-Language (p = 0.023) and DAS (p = 0.008) scores were more functionally dependent than those without. Discussion: Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37773576; info:eu-repo/semantics/altIdentifier/wos/WOS:001075364600001; volume:45; issue:3; firstpage:1087; lastpage:1095; numberofpages:9; journal:NEUROLOGICAL SCIENCES; https://hdl.handle.net/10281/520899 |
| DOI: |
10.1007/s10072-023-07074-3 |
| Availability: |
https://hdl.handle.net/10281/520899; https://doi.org/10.1007/s10072-023-07074-3 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.C4DA0279 |
| Database: |
BASE |