| Title: |
Computed tomography lung parenchymal descriptions in routine radiological reporting have diagnostic and prognostic utility in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension associated with lung disease |
| Authors: |
Dwivedi, K.; Condliffe, R.; Sharkey, M.; Lewis, R.; Alabed, S.; Rajaram, S.; Hill, C.; Saunders, L.; Metherall, P.; Alandejani, F.; Alkhanfar, D.; Wild, J.M.; Lu, H.; Kiely, D.G.; Swift, A.J. |
| Publisher Information: |
European Respiratory Society (ERS) |
| Publication Year: |
2022 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Background: Patients with pulmonary hypertension (PH) and lung disease may pose a diagnostic dilemma between idiopathic pulmonary arterial hypertension (IPAH) and PH associated with lung disease (PH-CLD). The prognostic impact of common computed tomography (CT) parenchymal features is unknown. Methods: 660 IPAH and PH-CLD patients assessed between 2001 and 2019 were included. Reports for all CT scans 1 year prior to diagnosis were analysed for common lung parenchymal patterns. Cox regression and Kaplan–Meier analysis were performed. Results: At univariate analysis of the whole cohort, centrilobular ground-glass (CGG) changes (hazard ratio, HR 0.29) and ground-glass opacification (HR 0.53) predicted improved survival, while honeycombing (HR 2.79), emphysema (HR 2.09) and fibrosis (HR 2.38) predicted worse survival (all p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/184331/1/Computed%20tomography%20lung%20parenchymal%20descriptions%20in%20routine%20radiological%20reporting%20have%20diagnostic%20and%20prognostic%20utility%20i.pdf; Dwivedi, K., Condliffe, R., Sharkey, M. et al. (12 more authors) (2022) Computed tomography lung parenchymal descriptions in routine radiological reporting have diagnostic and prognostic utility in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension associated with lung disease. ERJ Open Research, 8 (1). 00549-2021. |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/184331/; https://eprints.whiterose.ac.uk/id/eprint/184331/1/Computed%20tomography%20lung%20parenchymal%20descriptions%20in%20routine%20radiological%20reporting%20have%20diagnostic%20and%20prognostic%20utility%20i.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.C51C9376 |
| Database: |
BASE |