| Title: |
Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321 |
| Authors: |
Avutu, Viswatej; Weiss, Aaron R; Reed, Damon R; Ahmed, Safia K; Allen-Rhoades, Wendy A; Chen, Yen-Lin E; Davis, Lara E; Eaton, Bree R; Hawkins, Douglas S; Indelicato, Danny J; Patel, Shreyaskumar R; Randall, R Lor; Reinke, Denise K; Riedel, Richard F; Scharschmidt, Thomas J; Thornton, Katherine A; Wang, Dian; Janeway, Katherine A; Kopp, Lisa M |
| Source: |
Journal of Adolescent and Young Adult Oncology, vol 11, iss 3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2022 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Clinical Research (rcdc); Rare Diseases (rcdc); Cancer (rcdc); Patient Safety (rcdc); Pediatric (rcdc); Clinical Trials and Supportive Activities (rcdc); Pediatric Cancer (rcdc); Adolescent (mesh); Adult (mesh); Clinical Trials as Topic (mesh); Humans (mesh); Patient Participation (mesh); Sarcoma (mesh); Soft Tissue Neoplasms (mesh); Surveys and Questionnaires (mesh); Young Adult (mesh); NCTN; clinical trials; cooperative groups; enrollment barriers; survey; 1110 Nursing (for); 1112 Oncology and Carcinogenesis (for); 1117 Public Health and Health Services (for); 4205 Nursing (for-2020) |
| Subject Geographic: |
328 - 332 |
| Description: |
ARST1321, a trial of patients with advanced soft tissue sarcoma, was the first National Clinical Trials Network study codeveloped by pediatric and adult consortia with two treatment cohorts. We report on the findings of a survey to identify barriers to enrolling adolescent and young adult patients (15-39 years) onto the nonchemotherapy arm. The survey response rate was 31% with a 70% completion rate. Common identified reasons for low accrual in order of decreasing frequency included insufficient funding, lack of study awareness or interest, competing trials, toxicity concerns, philosophical differences in the therapy backbone, and regulatory and infrastructure barriers. Clinical Trials.gov ID: NCT02180867. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt9fs9m9nj; https://escholarship.org/uc/item/9fs9m9nj; https://escholarship.org/content/qt9fs9m9nj/qt9fs9m9nj.pdf |
| DOI: |
10.1089/jayao.2021.0103 |
| Availability: |
https://escholarship.org/uc/item/9fs9m9nj; https://escholarship.org/content/qt9fs9m9nj/qt9fs9m9nj.pdf; https://doi.org/10.1089/jayao.2021.0103 |
| Rights: |
public |
| Accession Number: |
edsbas.C57ACD5C |
| Database: |
BASE |