Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma
| Title: | Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma |
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| Authors: | Othman, Anjum; Kumar, Shiyam; Qureshi, Asim; Jawa, Zabah M.; Burney, Ikram A. |
| Source: | Case Reports in Oncology ; page 240-248 ; ISSN 1662-6575 |
| Publisher Information: | S. Karger AG |
| Publication Year: | 2023 |
| Description: | Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed through standard of care treatment for nonclear RCC. However, genetic analysis revealed a germline pathogenic variant of fumarate hydratase (FH) gene, and the patient had a sustained and durable response to pazopanib. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1159/000528697 |
| Availability: | https://doi.org/10.1159/000528697; https://karger.com/cro/article-pdf/16/1/240/4013006/000528697.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: | edsbas.C59DC109 |
| Database: | BASE |