| Title: |
A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan |
| Authors: |
Amprey, Joseph L.; Im, Jin S.; Turco, Salvatore J.; Murray, Henry W.; Illarionov, Petr A.; Besra, Gurdyal S.; Porcelli, Steven A.; Späth, Gerald F. |
| Source: |
The Journal of Experimental Medicine ; volume 200, issue 7, page 895-904 ; ISSN 1540-9538 0022-1007 |
| Publisher Information: |
Rockefeller University Press |
| Publication Year: |
2004 |
| Description: |
Natural killer (NK) T cells are activated by synthetic or self-glycolipids and implicated in innate host resistance to a range of viral, bacterial, and protozoan pathogens. Despite the immunogenicity of microbial lipoglycans and their promiscuous binding to CD1d, no pathogen-derived glycolipid antigen presented by this pathway has been identified to date. In the current work, we show increased susceptibility of NK T cell–deficient CD1d−/− mice to Leishmania donovani infection and Leishmania-induced CD1d-dependent activation of NK T cells in wild-type animals. The elicited response was Th1 polarized, occurred as early as 2 h after infection, and was independent from IL-12. The Leishmania surface glycoconjugate lipophosphoglycan, as well as related glycoinositol phospholipids, bound with high affinity to CD1d and induced a CD1d-dependent IFNγ response in naive intrahepatic lymphocytes. Together, these data identify Leishmania surface glycoconjugates as potential glycolipid antigens and suggest an important role for the CD1d–NK T cell immune axis in the early response to visceral Leishmania infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1084/jem.20040704 |
| Availability: |
https://doi.org/10.1084/jem.20040704; https://rupress.org/jem/article-pdf/200/7/895/1715062/jem2007895.pdf |
| Accession Number: |
edsbas.C59FD2D6 |
| Database: |
BASE |