| Title: |
Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda |
| Authors: |
Alupo, Patricia; Mugenyi, Levicatus; Katagira, Winceslaus; Kayongo, Alex; Nalunjogi, Joanitah; Siddharthan, Trishul; Hurst, John R; Kirenga, Bruce; Jones, Rupert C. |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2024 |
| Collection: |
Plymouth Marjon University Repository (CREST) |
| Subject Terms: |
R Medicine (General) |
| Description: |
Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with varied clinical and pathophysiological characteristics. Although there is increasing evidence that COPD in low-income and middle-income countries may have different clinical characteristics from that in high-income countries, little is known about COPD phenotypes in these settings. We describe the clinical characteristics and risk factor profile of a COPD population in Uganda. Methods: We cross sectionally analysed the baseline clinical characteristics of 323 patients with COPD aged 30 years and above who were attending 2 national referral outpatient facilities in Kampala, Uganda between July 2019 and March 2021. Logistic regression was used to determine factors associated with spirometric disease severity. Results: The median age was 62 years; 51.1% females; 93.5% scored COPD Assessment Test >10; 63.8% modified medical research council (mMRC) >2; 71.8% had wheezing; 16.7% HIV positive; 20.4% had a history of pulmonary tuberculosis (TB); 50% with blood eosinophilic count >3%, 51.7% had 3 or more exacerbations in the past year. Greater severity by Global initiative for Chronic Obstructive Lung Disease (GOLD) stage was inversely related to age (aOR=0.95, 95% CI 0.92 to 0.97), and obesity compared with underweight (aOR=0.25, 95% CI 0.07 to 0.82). Regarding clinical factors, more severe airflow obstruction was associated with SPO2 |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2052-4439 |
| Relation: |
https://marjon.repository.guildhe.ac.uk/id/eprint/17813/1/bmjresp-2023-001816.pdf; Alupo, Patricia, Mugenyi, Levicatus, Katagira, Winceslaus, Kayongo, Alex, Nalunjogi, Joanitah, Siddharthan, Trishul, Hurst, John R, Kirenga, Bruce and Jones, Rupert C. (2024) Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda. BMJ Open Respiratory Research, 11 (1). ISSN 2052-4439 |
| Availability: |
https://marjon.repository.guildhe.ac.uk/id/eprint/17813/ |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.C5C9DE0A |
| Database: |
BASE |