| Title: |
Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers With Preeclampsia |
| Authors: |
Jayet, Pierre-Yves; Rimoldi, Stefano F.; Stuber, Thomas; Salmòn, Carlos Salinas; Hutter, Damian; Rexhaj, Emrush; Thalmann, Sébastien; Schwab, Marcos; Turini, Pierre; Sartori-Cucchia, Céline; Nicod, Pascal; Villena, Mercedes; Allemann, Yves; Scherrer, Urs; Sartori, Claudio |
| Source: |
Circulation ; volume 122, issue 5, page 488-494 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2010 |
| Description: |
Background— Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the diseased placenta. We speculated that these factors pass the placental barrier and leave a defect in the circulation of the offspring that predisposes to a pathological response later in life. The hypoxia associated with high-altitude exposure is expected to facilitate the detection of this problem. Methods and Results— We assessed pulmonary artery pressure (by Doppler echocardiography) and flow-mediated dilation of the brachial artery in 48 offspring of women with preeclampsia and 90 offspring of women with normal pregnancies born and permanently living at the same high-altitude location (3600 m). Pulmonary artery pressure was roughly 30% higher (mean±SD, 32.1±5.6 versus 25.3±4.7 mm Hg; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circulationaha.110.941203 |
| DOI: |
10.1161/CIRCULATIONAHA.110.941203 |
| Availability: |
https://doi.org/10.1161/circulationaha.110.941203; https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.110.941203 |
| Accession Number: |
edsbas.C5CBA667 |
| Database: |
BASE |