| Title: |
The Intra-S Checkpoint Responses to DNA Damage |
| Authors: |
Iyer, Divya Ramalingam; Rhind, Nicholas |
| Contributors: |
Morningside Graduate School of Biomedical Sciences; Biochemistry and Molecular Pharmacology |
| Source: |
Genes ; 8 ; 2 |
| Publication Year: |
2022 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
ATR; Chk1; DNA damage; fork stability; intra-S checkpoint; origin regulation; Biochemistry; Cell Biology; Genetics; Molecular Biology |
| Description: |
Faithful duplication of the genome is a challenge because DNA is susceptible to damage by a number of intrinsic and extrinsic genotoxins, such as free radicals and UV light. Cells activate the intra-S checkpoint in response to damage during S phase to protect genomic integrity and ensure replication fidelity. The checkpoint prevents genomic instability mainly by regulating origin firing, fork progression, and transcription of G1/S genes in response to DNA damage. Several studies hint that regulation of forks is perhaps the most critical function of the intra-S checkpoint. However, the exact role of the checkpoint at replication forks has remained elusive and controversial. Is the checkpoint required for fork stability, or fork restart, or to prevent fork reversal or fork collapse, or activate repair at replication forks? What are the factors that the checkpoint targets at stalled replication forks? In this review, we will discuss the various pathways activated by the intra-S checkpoint in response to damage to prevent genomic instability. ; Interdisciplinary Graduate Program |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Link to Article in PubMed; Genes (Basel). 2017 Feb 17;8(2). pii: E74. doi:10.3390/genes8020074. Link to article on publisher's site; http://hdl.handle.net/20.500.14038/40291; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4096&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/3091; oapubs/3091 |
| DOI: |
10.3390/genes8020074 |
| Availability: |
https://doi.org/10.3390/genes8020074; https://hdl.handle.net/20.500.14038/40291; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4096&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/3091 |
| Rights: |
Copyright © 2017 by the authors. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.C6043F0E |
| Database: |
BASE |