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Vorapaxar in the secondary prevention of atherothrombotic events.

Title:	Vorapaxar in the secondary prevention of atherothrombotic events.
Authors:	Braunwald E; Morrow DA; Scirica BM; Bonaca MP; McCabe CH; Morin S; Fish P; Lamp J; Gershman E; Murphy S; Deenadayalu N; Skene A; Hill K; Bennett L; Strony J; Plat F; Berman G; Lipka L; Kilian A; He W; Liu X; Fox KA; Aylward P; Bassand JP; Betriu A; Bounameaux H; Corbalan R; Creager M; Dalby A; De Ferrari G; Dellborg M; Diehm CH; Dietz R; Goto S; Grande P; Gurbel P; Hankey G; Isaza D; Jensen P; Kiss R; Lewis B; Merlini P; Moliterno D; Morais J; Nicolau JC; Nieminen M; Nilsen D; Olin J; Ophuis TO; Paolasso E; Pichler M; Shinohara Y; Spinar J; Teal P; Tendera M; Theroux P; Thomassen L; Van de Werf F; White H; Wilcox R; Alberts M; Ameriso S; Diener H; Mohr J; Welch M; Wiviott SD; Awtry E; Berger C; Desai A; Gelfand E; Ho C; Leeman D; Link M; Norden A; Pande A; Rost N; Ruberg R; Silverman S; Singhal A; Vita J; Frye RL; Bailey KR; Easton J; Hochman J; Steg PG; Verheught F; Lee K; Mauro DO; Centurion A; Carlevaro O; Cardozo E; Cartasegna L; Soccini N; Farras HA; Molina Aguirre E; Duronto E; Arrechavala L; Rey R; Stilman A; Fernández H; Marinsalta G; Tartaglione J; Chekherdemian M; Povedano G; Casares E; Kantor P; Reges P; Cuneo C; Martinez G; MacKinnon I; Bagnato B; Fernandez A; Funosas C; Lozada A; Barilati P; Ferrari J; Ferrari N; Llanos J; Casaccia G; Giannaula R; García Méndez C; Cirio J; García Dávila C; Estol C; Chiezzo D; Ramirez J; Garrido S; López M; Hominal M; Bianchini MV; Ramos M; Verdini E; Herrera G; Monne H; Ioli P; Samudio MA; Rotta Escalante R; Tarulla A; Reich E; Perez G; Milesi R; Berli M; Marino J; Funes I; Prado A; Bezi M; Fernandez R; Rojas M; Cimbaro Canella JP; Galarza Salazan M; Chew D; Horsfall L; Claxton A; French J; O'Brien K; Nelson G; Loxton A; McCann A; Downey C; Aroney C; Cleave P; Worthley S; Roach A; Amerena J; Long A; Thompson P; Ferguson L; Fitzpatrick M; Mackenzie M; Youssef G; Goldsmith H; Jayasinghe R; Quinlan S; Arstall M; Rose J; Counsell J; Martin M; Crimmins D; Slattery A; Anderson C; Paraskevaidis T; Davis S; Silver G; Gerraty RP; Gapper J; Donnan G; Petrolo S; Whelan A; Tulloch G; Singh B; Campo Ma; Dick R; Savage C; Hill A; Conway B; Waites J; Keays P; Kopp K; Hainzer D; Podczeck Schweighofer A; Priesnitz T; Drexel H; Hagspiel V; Foeger B; Hilbe C; Trinka E; Sinadinoska D; Pilger E; Brodmann M; Stöllberger C; Jungbauer LV; Koppensteiner R; Hoke M; Grisold W; Berger O; Gaul GB; Fazekas N; Wandaller C; Stockenhuber F; Rek A; Willeit J; Zangerle A; Kiechl S; Sturm W; Theurl M; Gruber F; Schacherl S; Auer J; Primus C; Eber B; Ammer M; Hofer JF; Mayr H; Moser S; Hoellmueller I; Van der Werf F; Motte S; Jorion M; Schroë H; Zwinnen W; Vermassen F; Geenens M; De Wolf L; Briké C; De Deyn P; Ongena P; De Klippel N; Meeuwissen K; Desfontaines P; Tincani G; Vandermeeren Y; de Fays K; Pandolfo M; Alaerts N; Peeters A; Findik A; Tack P; deGrande E; Thijs V; Marcelis E; Van Landegem W; Vanhagendoren S; Vanhooren G; Schotte V; Celen H; Bes N; De Letter J; Holvoet G; Claerbout B; Verhamme P; Debaveye B; Bourgeois P; Debrabandere K; Stalpaert S; Dhondt E; De Maeseneire S; De Bleecker J; de Koning K; Vincent M; Tahon S; Monté C; Maes J; Vossaert R; Vandenhoven C; Roosen J; Vissers C; Sinnaeve P; de Velder L; Thoeng J; Cauwenberghs J; Deceuninck F; Nicolau J; Ardito WR; Queirantes C; de Araujo Filho JD; Queirantes CS; Ribeiro JP; Guizzardi SP; Chaves ML; Titton NF; Pereira AH; Webber I; da Silva DG Jr; Uehara RM; Brasileiro J; Maia LN; Souza A; Bodanese LC; Homem R; Friedrich MA; Macagnan AP; Dutra OP; Brum AB; Rossi PR; Herek L; Feitosa GS; Bernardes Ade S; Braga J; Rodrigues D; Guimarães A; Teixeira AB; Marin Neto JA; Tonani M; Piegas LS; Amato V; Leães P; Osorio RL; Ganem F; Vieira AP; Leao P; Kanashiro V; Franken RA; Martins EP; Gagliardi RJ; Silva L; Caffaro RA; Novaes GS; Carvalho A; Laet VL; Miranda F. Jr; Crippa BA; Saraiva JF; Ormundo CT; Speciali JG; Guandolini G; de Albuquerque DC; Silva V; Abrantes JA; Pinheiro L; Teixeira MS; Guanaes DF; Resende ES; Andrade SF; Alves ÁR Jr; Oliveira OM; Tauil CB; Araujo E; de Souza J; de Freitas GR; Horokosky AP; Barbosa EC; Muniz P; de Moraes JB Jr; Cabral M; Faria Neto JR; Belemer A; Paiva MS; Brito A; Hernandes ME; Amorim R; Pittella FJ; Brito HH; Kouz S; Roy M; Gosselin G; David M; Huynh T; Boudreault C; Heath J; Scott L; Bhargava R; Stafford C; Klinke WP; Martin L; Chan YK; Zaniol D; Rebane T; Abramovich M; Vizel S; Fox B; Kornder J; Breakwell L; Constance C; Gauthier M; Cleveland D; Valley S; Dion D; Morissette A; Vertes G; Ross B; Pandey AS; Byrne M; Abramson B; Sodhi N; Ervin F; Thiessen S; Halperin F; Stedham V; Pesant Y; Sardin V; Saw J; Tarry L; Pouliot J; Marquette S; Belisle P; Gagne D; Ducas J; Munoz A; Sussex B; Newman S; Madan M; Hsu E; Bata I; Cossett J; Glanz A; Vilag C; Paddock V; Collings E; Sabbah E; Chausse I; Fortin C; Lepage C; Chehayeb R; Viau C; Ma P; Seib M; Lamy A; Rizzo A; Rajakumar AR; Eikel L; Nigro F; Stoger S; Welsh R; Lindholm L; Parker JD; Webber S; Winkler L; Hannah G; Gupta M; Kubiak A; Mukherjee A; Bozek B; Nguyen M; Dufort L; Haichin R; Toyota V; Bujold S; Syan G; Chinnasane S; Houde G; Rousseau S; Poirier P; Lariviere M; Dupuis R; Ouimet F; Audet J; Darveau C; Labonte R; Rice T; Nawaz S; Cantor W; Robbins K; Boucher P. Jr; Roberge J; Zadra R; McPherson C; Prieto JC; Noriega V; Cereño C; Mestas M; Yovaniniz P; Ferrada W; Pincetti C; Torres G; Perez L; Villan C; Escobar E; Martin R; Padilla I; Ramirez M; Hormazabal R; Pedemonte O; Suazo E; Hasbun S; Mejias M; Cardenas F; Donoso L; Godoy I; Henriquez P; Mariné L; Vergara T; Juri C; Vergara E; Muñoz M; Solano E; Toro J; Cardenas S; Mendoza F; Martinez S; Saaibi JF; Castillo KM; Ruiz NP; Castillo T; Orozco A; Muñoz C; Martínez J; Lopez D; Ochoa J; Andrade J; Jaramillo C; Garces GP; Botero R; Cáceres A; Jaramillo M; Mejia C; Schlesinger A; Munevar V; Rodriguez J; Granados LM; Jaramillo N; Aristizabal C; Cano N; Salazar JC; Urina M; Manco T; Valenzuela C; Hernandez HJ; Delgado PS; Vagner B; Castaño LA; Ucros P; Tellez M; Delgado JA; Piedrahita CA; Crump J; Fernandez V; Quintero CA; Moreno M; Hernandez Triana E; Cuentas I; Accini JL; Accini M; Manzur F; Rivera E; Reynales H; Huertas D; Hovorka J; Filipovsky J; Hirmerova J; Peska S; Jura R; Kanovsky P; Herzig R; Jansky P; Fiala R; Kalita Z; Gatkova A; Bauer J; Fiksa J; Sedlacek J; Monhart Z; Bren J; Linhart A; Skalicka L; Vitovec J; Hlinomaz O; Parenica J; Soucek M; Rihacek I; Branny M; Sknouril L; Klimsa Z; Holub M; Línkova H; Rektor I; Mikulik R; Mayer O. Sr; Novakova B; Bar M; Brodova P; Polasek R; Sabl P; Kos P; Lorenc Z; Macel I; Graversen KH; Galatius S; Soderberg LH; Sillesen H; Madelung S; Overgård K; Stan V; Rasmussen LH; Mortensen B; Iversen HK; Back C; Olesen C; Christensen H; Pedersen A; Nielsen T; Hasain M; Tanggaard L; Husted S; Christensen LL; Haas L; Mickley H; Hosbond S; Rosenlund I; Jepsen J; Kaspersen BB; Bronnum Schou J; Hempel H; Nyvad O; Feldthaus B; Jensen BS; Jensen MK; Andersen G; Thomsen RB; Rokkedal J; Joergensen A; Bülow M; Jeppesen J; Lederballe O; Scheibel I; Sjol A; Larsen J; Graner M; Svahn T; Melin J; Kaakkomäki A; Airaksinen J; Vasankari T; Tatlisumak T; Metso M; Remes A; Näppä M; Jäkälä P; Sivenius J; Kalinen M; Roine RO; Ketola R; Bassand J; Pales D; Coisne D; Berger N; Galinier M; Rosolin N; Elbaz M; Lacassagne L; Montalescot G; Vignolles N; Gully C; Lepage I; Roynard J; Hamon M; Brucato S; Macquin Mavier I; Beitar T; Berthezene P; Medkour T; Amarenco P; Gueblaoui N; Timsit S; Riou D; Mahagne M; Suissa L; Quere I; Clouzot S; Emmerich J; Martinez I; Moulin T; Cole M; Hosseini H; Monod V; Cottin Y; Bichat F; Galley D; Beltra C; Samson Y; Pires R; Bura Riviere A; Pelvet B; Giroud M; Lecheneaut C; Ohlmann P; Ait m. bark Z; Farah B; Petit F; Caussin C; Braun C; Diehm C; Mehrhof F; Inkrot S; Darius H; Heinze H; Radke P; Kulikowsky C; Ferrari M; Utschig S; Strasser R; Haacke K; Felix SB; Bruder M; Nienaber C; Pfaff H; Sohn H; Baylacher M; Mudra H; Setzer P; Konstantinides S; Hallmann A; Kreuzer J; Tsoy I; Schneider P; Appel KF; Habermeier A; Zeiher AM; Kretschmer T; Mitrovic V; Lehinant S; Bohlscheid V; Palme B; Heuer H; Espinola Klein C; Savvidis S; Kleinertz K; Hänel J; Schmidt E; Schmidt A; Ringleb PA; Ludwig I; Dietzold M; Schaffranka A; Ranft J; Cegla C; Berrouschot J; Stoll A; Tanislav C; Brandtner MA; Rosenkranz M; Otto D; Görtler M; Barleben M; Haberl R; Miedl S; Maschke M; Schröder K; Aral Becher B; Herzog Hauff S; Guenther A; Herzau C; Hoffmann U; Roth Zetzsche S; Grond M; Becker M; Hamann G; Simon K; Köhrmann M; Glahn J; Wuttig H; Nabavi DG; Seraphin D; Schellong S; Frommhold R; Dichgans M; Doerr A; Blessing E; Buss I; Butter C; Bettin D; Grosch B; Blank E; Wong L; Liu R; Lee S; Kong S; Yu C; So E; Jakal Á; Masszi G; Czuriga I; Kapocsi J; Soós E; Csiba L; Fekete K; Valikovics A; Dioszeghy P; Muskóczki E; Csányi A; Matoltsy A; Yuval R; Bornstein N; Elimelech R; Chajek Shaul T; Bursztyn M; Hayek T; Hazbon K; Gavish D; Anat N; Wexler D; Azar P; Mosseri M; Tsirulnikov E; Rozenman Y; Logvinenko S; Tanne D; Don A; Gross B; Feldman Y; Klainman E; Genin Dmitrishin I; Eldar M; Eizenberg N; Atar S; Lasri E; Hammerman H; Aharoni G; Zimlichman R; Zuker S; Telman G; Afanasiev S; Katz A; Biton A; Goldhaber A; Goldhaber M; Elian D; Linor A; Meyuhas S; Tsalihin D; Kissos D; Lampl Y; Israelson M; Gottlieb S; Dotan L; Elis A; Karny M; Hussein O; Shestatski K; Brenner H; Segal E; Baldini U; Gavazzi A; Poloni M; Censori B; Aiazzi L; Maraglino C; Marenzi G; Specchia G; Tritto I; Golino P; CIANFLONE , DOMENICO; Martignoni A; Tamburino C; Rubartelli P; Ardissino D; Tadonio I; Stramba Badiale M; Cernuschi P; Nardulli R; Sommariva L; Giordano A; Berni A; Cavallini C; Fiscella A; Azzarelli S; Esposito G; Cassese S; Danzi G; Fattore L; Barbieri E; De Caterina R; Odero A; Puttini M; Corrada E; Monzini N; Vadalà A; Pistarini C; Scrutinio D; Ferratini M; Marcheselli S; Moretti L; Partemi L; Pupilella T; Lazzari A; Ledda A; Geraci G; Rasura M; Beccia M; Cassadonte F; Vatrano M; Bongiorni D; Mos L; Marcuzzi G; Murena E; Uguccioni L; Ferretti C; Piti ATerrosu P; Perrone PF; Marconi R; Grasso L; Severi S; Evola R; Russo N; Agnelli G; Paci C; Carugo S; Silvestri O; Testa R; Novo S.
Contributors:	Braunwald, E; Morrow, Da; Scirica, Bm; Bonaca, Mp; Mccabe, Ch; Morin, S; Fish, P; Lamp, J; Gershman, E; Murphy, S; Deenadayalu, N; Skene, A; Hill, K; Bennett, L; Strony, J; Plat, F; Berman, G; Lipka, L; Kilian, A; He, W; Liu, X; Fox, Ka; Aylward, P; Bassand, Jp; Betriu, A; Bounameaux, H; Corbalan, R; Creager, M; Dalby, A; De Ferrari, G; Dellborg, M; Diehm, Ch; Dietz, R; Goto, S; Grande, P; Gurbel, P; Hankey, G; Isaza, D; Jensen, P; Kiss, R; Lewis, B; Merlini, P; Moliterno, D; Morais, J; Nicolau, Jc; Nieminen, M; Nilsen, D; Olin, J; Ophuis, To; Paolasso, E; Pichler, M; Shinohara, Y; Spinar, J; Teal, P; Tendera, M; Theroux, P; Thomassen, L; Van de Werf, F; White, H; Wilcox, R; Alberts, M; Ameriso, S; Diener, H; Mohr, J; Welch, M; Wiviott, Sd; Awtry, E; Berger, C; Desai, A; Gelfand, E; Ho, C; Leeman, D; Link, M; Norden, A; Pande, A; Rost, N; Ruberg, R; Silverman, S; Singhal, A; Vita, J; Frye, Rl; Bailey, Kr; Easton, J; Hochman, J; Steg, Pg; Verheught, F; Lee, K; Mauro, Do; Centurion, A; Carlevaro, O; Cardozo, E; Cartasegna, L; Soccini, N; Farras, Ha; Molina Aguirre, E; Duronto, E; Arrechavala, L; Rey, R
Publication Year:	2012
Description:	BACKGROUND:Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1.METHODS:We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage.RESULTS:At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/22443427; info:eu-repo/semantics/altIdentifier/wos/WOS:000302608600004; volume:336; issue:15; firstpage:1404; lastpage:1413; numberofpages:10; journal:NEW ENGLAND JOURNAL OF MEDICINE; https://hdl.handle.net/20.500.11768/2957
Availability:	https://hdl.handle.net/20.500.11768/2957
Accession Number:	edsbas.C6273F21
Database:	BASE