| Title: |
Novel risk loci for COVID-19 hospitalization among admixed American populations |
| Authors: |
Diz-de Almeida, Silvia; Cruz, Raquel 0000-0002-6964-8898; Luchessi, Andre D.; Lorenzo-Salazar, José M; de Heredia, Miguel López; Quintela, Inés 0000-0002-0239-7975; González-Montelongo, Rafaela; Nogueira Silbiger, Vivian; Porras, Marta Sevilla; Tenorio Castaño, Jair Antonio 0000-0002-5308-2316; Nevado, Julian; Aguado, Jose María 0000-0002-9520-8255; Aguilar, Carlos; Aguilera-Albesa, Sergio 0000-0003-3540-1448; Almadana, Virginia; Almoguera, Berta; Alvarez, Nuria; Andreu-Bernabeu, Álvaro; Arana-Arri, Eunate 0000-0001-9759-333X; Arango, Celso 0000-0003-3382-4754; Arranz, María J; Artiga, Maria-Jesus; Baptista-Rosas, Raúl C; Barreda-Sánchez, María; Belhassen-Garcia, Moncef 0000-0002-2230-1256; Bezerra, Joao F.; Bezerra, Marcos A C; Boix-Palop, Lucía; Brion, María 0000-0001-7463-2148; Brugada, Ramón 0000-0001-6607-3032; Bustos, Matilde; Calderón, Enrique J. 0000-0002-3166-5086; Carbonell, Cristina 0000-0002-6271-5111; Castano, Luis 0000-0003-0437-9401; Castelao, Jose E. 0000-0002-5486-7238; Conde-Vicente, Rosa; Cordero-Lorenzana, M Lourdes 0000-0002-5875-509X; Cortes-Sanchez, Jose L.; Corton, Marta 0000-0003-0087-1626; Darnaude, M Teresa; De Martino-Rodríguez, Alba; Del Campo-Pérez, Victor 0000-0002-9424-9653; de Bustamante, Aranzazu Diaz 0000-0001-8757-0433; Domínguez-Garrido, Elena 0000-0002-2066-0511; Eirós, Rocío 0000-0002-9488-2555; Fariñas, María Carmen 0000-0002-9259-2730; Fernandez-Nestosa, María J; Fernández-Robelo, Uxía; Fernández-Rodríguez, Amanda 0000-0002-5110-2213; Fernández-Villa, Tania 0000-0002-9049-3026; Gago-Dominguez, Manuela 0000-0001-6713-4351; Gil-Fournier, Belén; Gómez-Arrue, Javier; Álvarez, Beatriz González 0000-0001-8144-5439; Bernaldo de Quirós, Fernan Gonzalez; González-Neira, Anna; González-Peñas, Javier 0000-0002-3850-3012; Gutiérrez-Bautista, Juan F.; Herrero, María José 0000-0002-6042-4185; Herrero-Gonzalez, Antonio; Jimenez-Sousa, María A; Lattig, María Claudia; Borja, Anabel Liger; Lopez-Rodriguez, Rosario 0000-0002-4713-0633; Mancebo, Esther; Martín-López, Caridad; Martín, Vicente 0000-0003-0552-2804; Martinez-Nieto, Oscar; Martinez-Lopez, Iciar; Martinez-Resendez, Michel F.; Martinez-Perez, Angel; Mazzeu, Juliana F.; Macías, Eleuterio Merayo; Minguez, Pablo 0000-0003-4099-9421; Cuerda, Victor Moreno; Oliveira, Silviene F.; Ortega-Paino, Eva; Parellada, Mara 0000-0001-7977-3601; Paz-Artal, Estela 0000-0002-0646-2375; Santos, Ney P C; Pérez-Matute, Patricia 0000-0003-2232-7971; Perez, Patricia; Pérez-Tomás, M Elena; Perucho, Teresa 0000-0001-5825-0166; Pinsach-Abuin, Mellina 0000-0001-7199-512X; Pita, Guillermo; Pompa-Mera, Ericka N.; Porras-Hurtado, Gloria L.; Pujol, Aurora 0000-0002-9606-0600; León, Soraya Ramiro; Resino, Salvador 0000-0001-8783-0450; Fernandes, Marianne R.; Rodríguez-Ruiz, Emilio 0000-0003-1447-877X; Rodriguez-Artalejo, Fernando 0000-0001-9317-5755; Rodriguez-Garcia, José A 0000-0003-2267-1887; Ruiz-Cabello, Francisco 0000-0002-2247-3293; Ruiz-Hornillos, Javier 0000-0002-0008-1678; Ryan, Pablo 0000-0002-4212-7419; Soria, José Manuel; Souto, Juan Carlos; Tamayo, Eduardo 0000-0001-8900-0944; Tamayo-Velasco, Alvaro 0000-0001-6202-5420; Taracido-Fernandez, Juan Carlos; Teper, Alejandro; Torres-Tobar, Lilian; Urioste, Miguel; Valencia-Ramos, Juan 0000-0002-6376-1566; Yáñez, Zuleima; Zarate, Ruth; de Rojas, Itziar; Ruiz, Agustín; Sánchez, Pascual; Real, Luis Miguel 0000-0003-4932-7429; Guillen-Navarro, Encarna 0000-0002-2915-7381; Ayuso, Carmen 0000-0002-9242-7065; Parra, Esteban; Riancho, José A 0000-0003-0691-8755; Rojas-Martinez, Augusto 0000-0003-3765-6778; Flores, Carlos 0000-0001-5352-069X; Lapunzina, Pablo 0000-0002-6324-4825; Carracedo, Ángel 0000-0003-1085-8986 |
| Publication Year: |
2024 |
| Subject Terms: |
COVID-19; genetics; genomics; GWAS; none; SNP |
| Description: |
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2050-084X |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39361370; info:eu-repo/semantics/altIdentifier/eissn/2050-084X; Novel risk loci for COVID-19 hospitalization among admixed American populations, 2024, vol. 13; https://investigacion.unirioja.es/documentos/670b30abd284363a97d9ad99 |
| DOI: |
10.7554/ELIFE.93666 |
| Availability: |
https://investigacion.unirioja.es/documentos/670b30abd284363a97d9ad99; https://doi.org/10.7554/ELIFE.93666 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C63470EC |
| Database: |
BASE |