Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study
| Title: | Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study |
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| Authors: | TM Drake; AB Docherty; EM Harrison; JK Quint; H Adamali; S Agnew; S Babu; CM Barber; S Barratt; E Bendstrup; S Bianchi; D Castillo Villegas; N Chaudhuri; F Chua; R Coker; W Chang; A Cranshaw; LE Crowley; D Dosanjh; CA Fiddler; IA Forrest; PM George; MA Gibbons; K Groom; S Haney; SP Hart; E Heiden; M Henry; L-P Ho; RK Hoyles; J Hutchinson; K Hurley; MG Jones; S Jones; M Kokosi; M Kreuter; LS Mackay; S Mahendran; G Margaritopoulos; M Molina-Molina; PL Molyneaux; A O'Brien; K O'Reilly; A Packham; H Parfrey; V Poletti; JC Porter; E Renzoni; P Rivera-Ortega; A-M Russell; G Saini; LG Spencer; GM Stella; H Stone; S Sturney; D Thickett; M Thillai; T Wallis; K Ward; AU Wells; A West; M Wickremasinghe; F Woodhead; G Hearson; L Howard; JK Baillie; PJM Openshaw; MG Semple; I Stewart; RG Jenkins |
| Publication Year: | 2020 |
| Collection: | Erasmus University Rotterdam (EUR): Figshare |
| Subject Terms: | COVID-19; IPF; ILD; Obesity; Lung Function; hospitalisation |
| Description: | Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | 10871/123098 |
| Availability: | https://figshare.com/articles/journal_contribution/Outcome_of_hospitalization_for_COVID-19_in_patients_with_interstitial_lung_disease_an_international_multicenter_study/29773949 |
| Rights: | CC BY-NC-ND |
| Accession Number: | edsbas.C6489B0C |
| Database: | BASE |