Evolution and host-specific adaptation of Pseudomonas aeruginosa .
| Title: | Evolution and host-specific adaptation of Pseudomonas aeruginosa . |
|---|---|
| Authors: | Weimann, Aaron; Dinan, Adam M; Ruis, Christopher; Bernut, Audrey; Pont, Stéphane; Brown, Karen; Ryan, Judy; Santos, Lúcia; Ellison, Louise; Ukor, Emem; Pandurangan, Arun P; Krokowski, Sina; Blundell, Tom L; Welch, Martin; Blane, Beth; Judge, Kim; Bousfield, Rachel; Brown, Nicholas; Bryant, Josephine M; Kukavica-Ibrulj, Irena; Rampioni, Giordano; Leoni, Livia; Harrison, Patrick T; Peacock, Sharon J; Thomson, Nicholas R; Gauthier, Jeff; Fothergill, Jo L; Levesque, Roger C; Parkhill, Julian; Floto, R Andres |
| Publisher Information: | American Association for the Advancement of Science (AAAS) |
| Publication Year: | 2024 |
| Collection: | The University of Liverpool Repository |
| Description: | The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These clones demonstrate varying intrinsic propensities for infecting CF or non-CF individuals (linked to specific transcriptional changes enabling survival within macrophages); have undergone multiple rounds of convergent, host-specific adaptation; and have eventually lost their ability to transmit between different patient groups. Our findings thus explain the pathogenic evolution of P. aeruginosa and highlight the importance of global surveillance and cross-infection prevention in averting the emergence of future epidemic clones. |
| Document Type: | article in journal/newspaper |
| File Description: | text |
| Language: | English |
| ISSN: | 0036-8075 |
| Relation: | https://livrepository.liverpool.ac.uk/3182784/1/27-03-24%20Weimann%20complete%20manuscript.pdf; Collapse authors list. Weimann, Aaron, Dinan, Adam M, Ruis, Christopher, Bernut, Audrey, Pont, Stéphane, Brown, Karen, Ryan, Judy, Santos, Lúcia, Ellison, Louise, Ukor, Emem et al (show 20 more authors) , Pandurangan, Arun P, Krokowski, Sina, Blundell, Tom L, Welch, Martin, Blane, Beth, Judge, Kim, Bousfield, Rachel, Brown, Nicholas, Bryant, Josephine M, Kukavica-Ibrulj, Irena, Rampioni, Giordano, Leoni, Livia, Harrison, Patrick T, Peacock, Sharon J, Thomson, Nicholas R, Gauthier, Jeff, Fothergill, Jo L orcid:0000-0002-7012-1508 , Levesque, Roger C, Parkhill, Julian and Floto, R Andres (2024) Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science (New York, N.Y.), 385 (6704). eadi0908-eadi0908. ISSN 0036-8075, 1095-9203 |
| DOI: | 10.1126/science.adi0908 |
| Availability: | https://livrepository.liverpool.ac.uk/3182784/; https://doi.org/10.1126/science.adi0908 |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.C666B800 |
| Database: | BASE |