Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.
| Title: | Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. |
|---|---|
| Authors: | Stewart, Iain; Jacob, Joseph; Porter, Joanna C; Liu, Bin; Tatler, Amanda L; Gomez, Nancy; Pugh, Matthew R; John, Alison E; Allen, Richard J; Blaikley, John F; Chaudhuri, Nazia; Denneny, Emma; Fabbri, Laura; George, Peter M; Guillen-Guio, Beatriz; Gooptu, Bibek; Hall, Ian P; Ho, Ling Pei; Jarrold, Ian; Johnson, Simon; Jones, Mark G; Khan, Fasihul; Mehta, Puja; Mitchell, Jane; Molyneaux, Philip L; Pearl, John E; Piper Hanley, Karen; Platé, Manuela; Quinn, Valerie; Rivera-Ortega, Pilar; Saunders, Laura C; Smith, David JF; Spears, Mark; Spencer, Lisa G; Stanel, Stefan C; Thompson, AA Roger; Walsh, Simon; Wild, Jim M; Wootton, Dan G; Docherty, Annemarie B; Gleeson, Fergus; Greenhalf, William; Harrison, Ewen M; Lone, Nazir; Quint, Jennifer; Maslova, Anastasia; Pohl, Moritz; Stephens, Adam; Young, Simon; Singapuri, Amisha; Shikotra, Aarti; Sereno, Marco; Saunders, Ruth M; Richardson, Matthew; Raman, Betty; Poinasamy, Krisnah; McAuley, Hamish JC; Marks, Michael; Leavy, Olivia C; Houchen-Wolloff, Linzy; Horsley, Alex; Harris, Victoria C; Greening, Neil; Evans, Rachael A; Elneima, Omer; Chalmers, James D; Brightling, Christopher E; Chambers, Rachel C; Wain, Louise V; Jenkins, R Gisli; PHOSP-COVID Collaborative Group and the UKILD Consortium |
| Publisher Information: | Elsevier BV |
| Publication Year: | 2026 |
| Collection: | London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: | BACKGROUND: Long term respiratory symptoms are reported following recovery of acute COVID-19 infection and residual lung abnormalities (RLA) on follow-up thoracic computed tomography (CT) after COVID-19 hospitalisation have been observed. It is unknown whether RLA are associated with epithelial lung injury. METHODS: Plasma was sampled from the observational Post HOSPitalisation-COVID cohort at five months post-hospitalisation. Epithelial injury biomarkers Krebs von den Lungen-6 (KL-6), matrix metalloproteinase 7 (MMP-7), surfactant protein-D (SP-D) and surfactant protein-A (SP-A) were assayed. In those without follow-up CT, RLA at-risk was defined by percent predicted DLCO |
| Document Type: | article in journal/newspaper |
| File Description: | text |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | https://researchonline.lshtm.ac.uk/id/eprint/4678921/1/stewart-etal-2026-residual-lung-abnormality-following-covid-19-hospitalisation-is-characterised-by-biomakers-of-epithelial-injury.pdf; Stewart, Iain; Jacob, Joseph; Porter, Joanna C; Liu, Bin; Tatler, Amanda L; Gomez, Nancy; Pugh, Matthew R; John, Alison E; Allen, Richard J; Blaikley, John F; +61 more.Chaudhuri, Nazia; Denneny, Emma; Fabbri, Laura; George, Peter M; Guillen-Guio, Beatriz; Gooptu, Bibek; Hall, Ian P; Ho, Ling Pei; Jarrold, Ian; Johnson, Simon; Jones, Mark G; Khan, Fasihul; Mehta, Puja; Mitchell, Jane; Molyneaux, Philip L; Pearl, John E; Piper Hanley, Karen; Platé, Manuela; Quinn, Valerie; Rivera-Ortega, Pilar; Saunders, Laura C; Smith, David JF; Spears, Mark; Spencer, Lisa G; Stanel, Stefan C; Thompson, AA Roger; Walsh, Simon; Wild, Jim M; Wootton, Dan G; Docherty, Annemarie B; Gleeson, Fergus; Greenhalf, William; Harrison, Ewen M; Lone, Nazir; Quint, Jennifer; Maslova, Anastasia; Pohl, Moritz; Stephens, Adam; Young, Simon; Singapuri, Amisha; Shikotra, Aarti; Sereno, Marco; Saunders, Ruth M; Richardson, Matthew; Raman, Betty; Poinasamy, Krisnah; McAuley, Hamish JC; Marks, Michael ORCID logo; Leavy, Olivia C; Houchen-Wolloff, Linzy; Horsley, Alex; Harris, Victoria C; Greening, Neil; Evans, Rachael A; Elneima, Omer; Chalmers, James D; Brightling, Christopher E; Chambers, Rachel C; Wain, Louise V; Jenkins, R Gisli; and PHOSP-COVID Collaborative Group and the UKILD Consortium (2026) Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. EBioMedicine, 124. 106134-. ISSN 2352-3964 DOI:10.1016/j.ebiom.2026.106134 |
| DOI: | 10.1016/j.ebiom.2026.106134 |
| Availability: | https://researchonline.lshtm.ac.uk/id/eprint/4678921/; https://doi.org/10.1016/j.ebiom.2026.106134 |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.C699F2C0 |
| Database: | BASE |