| Title: |
The revised-FINDRISC: A tool for type 2 diabetes risk screening across diverse populations incorporating sociodemographic indicators |
| Authors: |
Vitoratou, Dimitra-Irinna; Dimakopoulou, Konstantina; Mavrogianni, Christina; Karaglani, Eva; Argyropoulou, Matzourana; Cardon, Greet; Usheva, Natalya; Iotova, Violeta; Tankova, Tsvetalina; Giménez-Legarre, Natalia; Moreno, Luis A.; Toti, Florian; Makrilakis, Konstantinos; Doracaj, Ditila; Imre, Rurik; Torzsa, Péter; Lindström, Jaana; Panagiotakos, Demosthenes; Manios, Yannis |
| Publication Year: |
2026 |
| Collection: |
Digital Repository of University of Zaragoza (ZAGUAN) |
| Description: |
Aim Τo develop a revised version of the FINDRISC tailored to improve the identification of individuals at high risk for type 2 diabetes (T2D) across diverse populations. Methods The revised-FINDRISC was developed using pooled harmonized baseline data from the multinational Feel4Diabetes (NCT02393872; N = 3526) and DigiCare4You (NCT05648383; N = 2156) studies. Validation utilized data from the 20-year ATTICA cohort study in Greece. Original FINDRISC components were analyzed using Fisher’s Linear Discriminant Analysis followed by supervised stepwise logistic regression to identify significant T2D cross-sectional predictors. The revised-FINDRISC was developed by re-scoring or excluding original items and incorporating new predictors, generating an integer-based score to enhance usability. Results The revised-FINDRISC significantly improved accuracy in identifying current T2D risk over the original, with an overall AUC of 0.911(95%CI: 0.901,0.922) versus 0.832(0.815,0.846). When stratified by country economic classification, the revised score outperformed the original across all groups: LMICs: 0.881(0.864,0.898) vs. 0.815(0.793,0.837), South European-HICs: 0.891(0.867,0.916) vs. 0.839(0.811,0.869), and North European-HICs: 0.921(0.872,0.971) vs. 0.844(0.742,0.949). A clinical threshold score of 13/24 in the revised-FINDRISC offers optimal sensitivity and specificity for identifying individuals at risk of T2D. Conclusion Enhanced with demographic, socio-economic, and clinical factors, the revised-FINDRISC potentially represents a substantive advancement in T2D screening, supporting early detection and targeted prevention. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement/EC/H2020/643708/EU/Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe/Feel4Diabetes; This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643708-Feel4Diabetes; info:eu-repo/grantAgreement/EC/H2020/945246 /EU/An intersectoral innovative solution involving DIGItal tools, empowering families and integrating community CARE services for the prevention and management of type 2 diabetes and hypertension/DigiCare4You; This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 945246 -DigiCare4You; http://zaguan.unizar.es/record/170115 |
| DOI: |
10.1016/j.annepidem.2026.110064 |
| Availability: |
http://zaguan.unizar.es/record/170115; https://doi.org/10.1016/j.annepidem.2026.110064 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C6AF0366 |
| Database: |
BASE |