| Title: |
Decrease in the cortex/striatum metabolic ratio on [18F]-FDG PET: a biomarker of autoimmune encephalitis |
| Authors: |
Frison, Eric; PROUST-LIMA, Cecile; Mangin, Jean-Francois; Habert, Marie-Odile; Bombois, Stephanie; Ousset, Pierre-Jean; Pasquier, Florence; Hanon, Olivier; Paquet, Claire; Gabelle, Audrey; Ceccaldi, Mathieu; Annweiler, Cédric; Krolak-Salmon, Pierre; Béjot, Yannick; Belin, Catherine; Wallon, David; Sauvee, Mathilde; Beaufils, Emilie; Bourdel-Marchasson, Isabelle; Jalenques, Isabelle; Chupin, Marie; Chêne, Geneviève; Dufouil, Carole; De Leiris, Nicolas; Ruel, Berangère; Vervandier, Jean; Boucraut, José; Grimaldi, Stephan; Horowitz, Tatiana; Pelletier, Jean; Fluchere, Frederique; Campion, Jacques-Yves; Kaphan, Elsa; Guedj, Eric |
| Contributors: |
Service de médecine nucléaire Marseille; Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone CHU - APHM (TIMONE); Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP); Institut FRESNEL (FRESNEL); Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)- Hôpital de la Timone CHU - APHM (TIMONE); Centre Européen de Recherche en Imagerie médicale (CERIMED); Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS) |
| Source: |
ISSN: 1619-7070. |
| Publisher Information: |
HAL CCSD; Springer Verlag (Germany) |
| Publication Year: |
2021 |
| Collection: |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| Subject Terms: |
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Objective To assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition. Methods The study sample was derived from MEMENTO, a cohort of French adults recruited in memory clinics and screened for either isolated subjective cognitive complaints or mild cognitive impairment. Diabetes was defined based on blood glucose assessment, use of antidiabetic agent, or self-report. We used structural equation modeling to assess whether latent variables of AD pathology (PET mean amyloid uptake, Aβ 42 /Aβ 40 ratio, and CSF phosphorylated tau), SVD (white matter hyperintensities volume and visual grading), and neurodegeneration (mean cortical thickness, brain parenchymal fraction, hippocampal volume, and mean fluorodeoxyglucose uptake) mediate the association between diabetes and a latent variable of cognition (5 neuropsychological tests), adjusting for potential confounders. Results There were 254 (11.1%) participants with diabetes among 2,288 participants (median age 71.6 years; 61.8% women). The association between diabetes and lower cognition was significantly mediated by higher neurodegeneration (standardized indirect effect: −0.061, 95% confidence interval: −0.089, −0.032), but not mediated by SVD and AD markers. Results were similar when considering latent variables of memory or executive functioning. Conclusion In a large clinical cohort in the elderly, diabetes is associated with lower cognition through neurodegeneration, independently of SVD and AD biomarkers. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
hal-03363845; https://hal.archives-ouvertes.fr/hal-03363845 |
| DOI: |
10.1007/s00259-021-05507-9 |
| Availability: |
https://hal.archives-ouvertes.fr/hal-03363845; https://doi.org/10.1007/s00259-021-05507-9 |
| Accession Number: |
edsbas.C6B3611E |
| Database: |
BASE |