Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial
| Title: | Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial |
|---|---|
| Authors: | Giamarellos-Bourboulis, Evangelos J; Kotsaki, Antigone; Kotsamidi, Ioanna; Efthymiou, Aikaterini; Koutsoukou, Vasiliki; Ehler, Johannes; Paridou, Alexandra; Frantzeskaki, Frantzeska; Müller, Marcella C A; Pickkers, Peter; Meylan, Sylvain; Nikolopoulos, Ioannis; Lupse, Mihaela; Gavala, Alexandra; Vlachogianni, Glykeria; Solomonidi, Nicky; Alevizou, Antonia; Kondili, Eumorfia; Antoniadou, Eleni; Nakou, Maria; Markou, Nikolaos; Hatziagelaki, Erifili; Prekates, Athanassios; Komnos, Apostolos; Bakkerus, Lieke; Slim, Marleen A; Dalekos, George N; Karapanagiotou, Areti; Ktena, Sofia; De Pascale, Gennaro; Koulouras, Vassileios; Psarrakis, Christos; Massa, Eleni; Dakou, Konstantina; Pazvanti, Chrisoula; Ioakeimidou, Aikaterini; Tsangaris, Iraklis; Antonakos, Nikolaos; Vlaar, Alexander P J; Anisoglou, Souzana; Calandra, Thierry; Papaioannou, Vasilios; Myrianthefs, Pavlos; Patrani, Maria; Alamanos, Ioannis; Antonelli, Massimo; van der Meer, Jos W M; van der Poll, Tom; Wiersinga, W Joost; Ntaganou, Maria; Gkeka, Eleni; Bauer, Michael; Mouloudi, Eleni; Netea, Mihai G |
| Contributors: | ImmunoSep Study Group; Bogosian, Artemis; Bourika, Vasiliki; Chatzianastasiou, Athanasia; Dimopoulou, Effrosyni; Dimopoulos, George; Efstratiou, Leda; Florou, Eleni; Katsigianni, Eleni; Kanellakopoulou, Paraskevi; Kollia, Myrto; Konstantinou, Elli; Koufargyris, Panagiotis; Kyprianou, Miltiades; Micha, Styliani; Neophytou, Onisiphoros; Nikolakea, Melina; Olntasi, Elisavet; Papatheodosiou, Dimitra; Perraki, Varvara; Rimpa, Christina Maria; Sideratou, Christina; Sidiropoulou, Chrysanthi; Sofianopoulos, Emmanouel; Stylianakis, Emmanouil; Tavoulareas, Georgios; Theodorou, Ioannis; Papadopoulos, Antonios; Bolanou, Amalia; Damoraki, Georgia; Gkavogianni, Theologia; Katrini, Konstantina; Leventogiannis, Konstantinos; Safarika, Asimina; Siampanos, Athanasios; Katopodis, Sokratis; Armaganidis, Apostolos; Karakike, Eleni; Kyriazopoulou, Evdoxia; Rizos, Michail; Gatselis, Nikolaos; Georgiadou, Sara; Giannoulis, Georgios; Lygoura, Vasiliki; Perifanos, Georgios; Samakidou, Anna; Stefos, Angelos; Sveroni, Dafni; Vatidis, Georgios; Boukas, Petros; Mantis, Konstantinos; Markopoulou, Dimitra; Papadaki, Eleni; Demertzi, Eirini; Dimou, Konstantina; Ioannou, Eirini; Kantas, Dimitrios; Lagos, Nikolaos; Papathanakos, Georgios; Papathanasiou, Athanasios; Paschali, Maria; Peristeri, Sofia; Saranti, Maria; Stefanatou, Nikoletta; Vagia, Maria; Nikolaou, Konstantina; Theodorou, Vasiliki; Antypa, Elli; Chassou, Eleftheria; Kosmidis, Kosmas; Mourouzidou, Violetta; Panagiotidou, Evangelia; Pitsoulis, Achillefs; Tassioudis, Polychronis; Vasileiou, Maria; Aimoniotou-Georgiou, Eleni; Apostolidou, Eirini; Bakas, Apostolos; Fylaki, Eirini; Papandreou, Eleni; Papathanasiou, Maria; Psaroulis, Konstantinos; Aidoni, Zoi; Amoiridou, Pinelopi; Birmpa, Vasiliki; Karvouniaris, Marios; Pagioulas, Konstantinos; Primikyri, Stella-Niki; Soultati, Ioanna; Tsakalidis, Alexandros; Tsianta, Stella; Tsiantas, Christos; Tryfonidou, Iliana; Veliki, Nopi; Veroniki, Foteini; Alevroudis, Ioannis; Bargiota, Triantafyllenia; Bosmou, Zoi; Kafantaris, Ioannis; Karapiperidis, Damianos |
| Publication Year: | 2026 |
| Collection: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Description: | Sepsis is heterogeneous, and the optimal strategy for tailoring immunotherapy is uncertain. To investigate whether precision immunotherapy guided by the presence of macrophage activation-like syndrome or sepsis-induced immunoparalysis improves organ dysfunction by day 9. A randomized, double-blind, double-dummy, placebo-controlled clinical trial conducted in 6 countries. Patients with sepsis, defined by Sepsis-3, were included if they had community-acquired or hospital-acquired pneumonia or ventilator-associated pneumonia or bacteremia and sepsis and had displayed either macrophage activation-like syndrome (blood ferritin >4420 ng/mL) or sepsis-induced immunoparalysis (blood ferritin ≤4420 ng/mL and |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 0098-7484 |
| Relation: | Journal of the American Medical Association; https://iris.unil.ch/handle/iris/278124; 001637998400001 |
| DOI: | 10.1001/jama.2025.24175 |
| Availability: | https://iris.unil.ch/handle/iris/278124; https://doi.org/10.1001/jama.2025.24175 |
| Accession Number: | edsbas.C6BFACAD |
| Database: | BASE |