| Title: |
Blunted coronary flow reserve in systemic sclerosis |
| Authors: |
Sulli, A.; Ghio, M.; Bezante, G. P.; Deferrari, L.; Craviotto, C.; Sebastiani, V.; Setti, M.; Barsotti, A.; Cutolo, M.; Indiveri, F. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2004 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Clinical |
| Description: |
Objectives . We investigated whether the non-invasive determination of coronary flow reserve (CFR), as evaluated by transthoracic Doppler echocardiography, might be a potential method to detect early dysfunction of cardiovascular system in patients affected by systemic sclerosis (SSc) without clinical signs or symptoms of cardiac impairment. The possible correlations between the CFR values and the duration of the disease, specific autoantibodies and cutaneous involvement subsets were investigated. Methods . Forty-four consecutive patients affected by SSc were analysed. The CFR was detected in the distal left anterior descending coronary artery by contrast-enhanced transthoracic second harmonic Doppler in all SSc patients and in 16 healthy controls. CFR was assessed at rest and during hyperaemia induced by administration of adenosine at 0.14 mg/kg/min over 5 min. The CFR was calculated as the ratio between hyperaemic (peak adenosine infusion) and resting peak diastolic velocity (PdvCFR) and resting velocity time integral (VtiCFR). Past medical history was carefully investigated. Results . Both PdvCFR and VtiCFR were significantly reduced in SSc patients when compared with controls ( P |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://rheumatology.oxfordjournals.org/cgi/content/short/43/4/505; http://dx.doi.org/10.1093/rheumatology/keh087 |
| DOI: |
10.1093/rheumatology/keh087 |
| Availability: |
http://rheumatology.oxfordjournals.org/cgi/content/short/43/4/505; https://doi.org/10.1093/rheumatology/keh087 |
| Rights: |
Copyright (C) 2004, British Society for Rheumatology |
| Accession Number: |
edsbas.C6EA18B |
| Database: |
BASE |