| Title: |
Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study |
| Authors: |
Walker, Sarah; Goodfellow, Henry; Pookarnjanamorakot, Patra; Murray, Elizabeth; Bindman, Julia; Blandford, Ann; Bradbury, Katherine; Cooper, Belinda; L Hamilton, Fiona; R Hurst, John; Hylton, Hannah; Linke, Stuart; Pfeffer, Paul; Ricketts, William; Robson, Chris; A Stevenson, Fiona; Sunkersing, David; Wang, Jiunn; Gomes, Manuel; Henley, William; With Covid Recovery Collaboration, Living |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2023 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
Objectives To describe self-reported characteristics and symptoms of treatment-seeking patients with post-COVID-19 syndrome (PCS). To assess the impact of symptoms on health-related quality of life (HRQoL) and patients’ ability to work and undertake activities of daily living.Design Cross-sectional single-arm service evaluation of real-time user data.Setting 31 post-COVID-19 clinics in the UK.Participants 3754 adults diagnosed with PCS in primary or secondary care deemed suitable for rehabilitation.Intervention Patients using the Living With Covid Recovery digital health intervention registered between 30 November 2020 and 23 March 2022.Primary and secondary outcome measures The primary outcome was the baseline Work and Social Adjustment Scale (WSAS). WSAS measures the functional limitations of the patient; scores of ≥20 indicate moderately severe limitations. Other symptoms explored included fatigue (Functional Assessment of Chronic Illness Therapy–Fatigue), depression (Patient Health Questionnaire–Eight Item Depression Scale), anxiety (Generalised Anxiety Disorder Scale, Seven-Item), breathlessness (Medical Research Council Dyspnoea Scale and Dyspnoea-12), cognitive impairment (Perceived Deficits Questionnaire, Five-Item Version) and HRQoL (EQ-5D). Symptoms and demographic characteristics associated with more severe functional limitations were identified using logistic regression analysis.Results 3541 (94%) patients were of working age (18-65); mean age (SD) 48 (12) years; 1282 (71%) were female and 89% were white. 51% reported losing ≥1 days from work in the previous 4 weeks; 20% reported being unable to work at all. Mean WSAS score at baseline was 21 (SD 10) with 53% scoring ≥20. Factors associated with WSAS scores of ≥20 were high levels of fatigue, depression and cognitive impairment. Fatigue was found to be the main symptom contributing to a high WSAS score.Conclusion A high proportion of this PCS treatment-seeking population was of working age with over half reporting moderately severe or worse ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/48699898; BMJ Open; Volume 13; Issue 6 |
| DOI: |
10.1136/bmjopen-2022-069217 |
| Availability: |
https://doi.org/10.1136/bmjopen-2022-069217; https://nottingham-repository.worktribe.com/file/48699898/1/Impact%20of%20fatigue%20as%20the%20primary%20determinant%20of%20functional%20limitations%20among%20patients%20with%20post-COVID-19%20syndrome%3A%20a%20cross-sectional%20observational%20study; https://nottingham-repository.worktribe.com/output/48699898 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.C72F9EF1 |
| Database: |
BASE |