| Title: |
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer |
| Authors: |
Block, Matthew S.; Vierkant, Robert A.; Rambau, Peter F.; Winham, Stacey J.; Wagner, Philipp; Traficante, Nadia; Toloczko, Aleksandra; Tiezzi, Daniel G.; Taran, Florin Andrei; Sinn, Peter; Sieh, Weiva; Sharma, Raghwa; Rothstein, Joseph H.; Ramon y Cajal, Teresa; Paz-Ares, Luis; Oszurek, Oleg; Orsulic, Sandra; Ness, Roberta B.; Nelson, Gregg; Modugno, Francesmary; Menkiszak, Janusz; McGuire, Valerie; McCauley, Bryan M.; Mack, Marie; Lubinski, Jan; Longacre, Teri A.; Li, Zheng; Lester, Jenny; Kennedy, Catherine J.; Kalli, Kimberly R.; Jung, Audrey Y.; Johnatty, Sharon E.; Jimenez-Linan, Mercedes; Jensen, Allan; Intermaggio, Maria Paola; Hung, Jillian; Herpel, Esther; Hernandez, Brenda Y.; Hartkopf, Andreas D.; Harnett, Paul R.; Ghatage, Prafull; García-Bueno, José María; Gao, Bo; Fereday, Sian; Eilber, Ursula; Edwards, Robert P.; de Sousa, Christiani B.; de Andrade, Jurandyr M.; Chudecka-Glaz, Anita; Chenevix-Trench, Georgia; Cazorla-Jiménez, Alicia; Brucker, Sara Y.; Bowtell, David D.; Green, Adele C.; Webb, Penelope M.; deFazio, Anna; Gertig, Dorota M.; Moore, Sue; Harrap, Karen; Sadkowsky, Troy; Pandeya, Nirmala; Malt, Maryrose K.; Mellon, Anne; Robertson, Randall; Vanden Bergh, Trish; Jones, Marian; Mackenzie, Patricia; Maidens, Jayne; Nattress, Kathryn; Chiew, Yoke Eng; Stenlake, Annie; Sullivan, Helen; Alexander, Barbara; Ashover, Pat; Brown, Susan; Corrish, Tracy; Green, Lyn; Jackman, Leah M.; Ferguson, Kaltin H.; Martin, Karen; Martyn, Adam C.; Ranieri, Barbara A.; White, Joanne; Jayde, Victoria; Mamers, Pamela M.; Bowes, Leanne; Galletta, Laura; Giles, Debra; Hendley, Joy; Alsop, Kathryn; Schmidt, Trudy; Shirley, Helen; Ball, Collen; Young, Cherry; Viduka, Suzanna; Tran, Hoa; Bilic, Sanela; Glavinas, Lydia; Brooks, Julia; Stuart-Harris, Robin C.; Kirsten, Fred; Rutovitz, Josie J.; Clingan, Peter; Glasgow, Amanda; Proietto, Anthony M.; Braye, Stephen; Otton, Greg; Shannon, Jennifer A.; Bonaventura, Tony; Stewart, James F.; Begbie, Stephen D.; Friedlander, Michael; Bell, David R.; Baron-Hay, Sally E.; Ferrier, Allan J.; Gard, Gregory B.; Nevell, David F.; Pavlakis, Nick; Valmadre, Susan; Young, Barbara; Camaris, Catherine; Crouch, Roger; Edwards, Lyndal S.; Hacker, Neville; Marsden, Donald E.; Robertson, Gregory; Beale, Philip J.; Beith, Jane; Carter, Jodi; Dalrymple, Christopher J.; Houghton, Roger; Russell, Prudence Anne; Links, Matthew; Grygiel, John J.; Hill, Jane; Brand, Alison Hilary; Byth Wilson, Karen; Jaworski, Richard C.; Wain, Gerard; Ward, Bruce Gordon; Papadimos, David J.; Crandon, Alexander J.; Cummings, Margaret C.; Horwood, Keith R.; Obermair, Andreas; Perrin, Lew; Wyld, David; Nicklin, James Lindsay; Davy, Margaret Lorraine Jeune; Oehler, Martin K.; Hall, Chris; Dodd, Thomas J.; Healy, Tabitha; Pittman, Kenneth B.; Henderson, Douglas Warrington; Miller, John; Pierdes, John; Blomfield, Penny I.; Challis, David R.; McIntosh, Robert; Parker, Andrew E.; Brown, Bob; Rome, Robert M.; Allen, David G.; Grant, Peter Thomas; Hyde, Simon E.; Laurie, Rohan; Robbie, Melissa J.; Healy, David Lindsay; Jobling, Thomas W.; Manolitsas, Tom P.; McNealage, Jane; Rogers, Peter Adrian Walton; Susil, Beatrice J.; Sumithran, Eric; Simpson, Ian J.; Phillips, Kelly-Anne; Rischin, Danny; Fox, Stephen; Johnson, Daryl S.; Lade, Stephen; Loughrey, Maurice Bernard; O'Callaghan, Neil; Murray, William K.; Waring, Paul M.; Billson, Virginia R.; Pyman, Jan M.; Neesham, Deborah E.; Quinn, Michael Anthony; Underhill, Craig; Bell, Richard; Ng, Leong Fook; Blum, Robert H.; Ganju, Vinod; Hammond, Ian G.; Leung, Yee; McCartney, Anthony J.; Buck, Martin; Haviv, Izhak; Purdie, David M.; Whiteman, David C.; Zeps, Nikolajs; Alsop, Jennifer; Whittemore, Alice S.; Steed, Helen; Staebler, Annette; Moysich, Kirsten B.; Menon, Usha; Koziak, Jennifer M.; Kommoss, Stefan; Kjaer, Susanne K.; Kelemen, Linda E.; Karlan, Beth Y.; Huntsman, David G.; Høgdall, Estrid; Gronwald, Jacek; Goodman, Marc T.; Gilks, Blake; García García, María José; Fasching, Peter A.; Deen, Suha; Chang-Claude, Jenny; Candido dos Reis, Francisco J.; Campbell, Ian; Brenton, James D.; Benitez, Javier; Pharoah, Paul D.P.; Köbel, Martin; Ramus, Susan J.; Goode, Ellen L.; Universitat Autònoma de Barcelona |
| Publication Year: |
2018 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Description: |
To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
19425546 |
| Relation: |
Mayo Clinic Proceedings; Vol. 93 Núm. 3 (january 2018), p. 307-320; https://ddd.uab.cat/record/287399; urn:10.1016/j.mayocp.2017.10.023; urn:oai:ddd.uab.cat:287399; urn:scopus_id:85042274578; urn:articleid:19425546v93n3p307; urn:pmid:29502561; urn:pmcid:PMC5870793; urn:oai:pubmedcentral.nih.gov:5870793 |
| Availability: |
https://ddd.uab.cat/record/287399 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.C74B1735 |
| Database: |
BASE |