| Title: |
Emerging Non-Breast Implant-Associated Lymphomas: A Systematic Review |
| Authors: |
Di Napoli A.; Fruscione S.; Mazzola S.; Amodio R.; Graziano G.; Mannino R.; Zarcone M.; Bertolazzi G.; Bonaccorso N.; Sciortino M.; De Bella D. D.; Savatteri A.; Belluzzo M.; Norrito C. A.; Sparacino R.; Contiero P.; Tagliabue G.; Costantino C.; Mazzucco W. |
| Contributors: |
Di Napoli, A.; Fruscione, S.; Mazzola, S.; Amodio, R.; Graziano, G.; Mannino, R.; Zarcone, M.; Bertolazzi, G.; Bonaccorso, N.; Sciortino, M.; De Bella, D.D.; Savatteri, A.; Belluzzo, M.; Norrito, C.A.; Sparacino, R.; Contiero, P.; Tagliabue, G.; Costantino, C.; Mazzucco, W. |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute (MDPI) |
| Publication Year: |
2024 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
anaplastic large-cell lymphoma; emerging lymphomas; implants; medical devices |
| Description: |
Background: Medical devices used for functional or esthetic purposes improve health and quality of life; however, they are not risk-free. Anaplastic large-cell lymphoma (ALCL), associated with breast implants, is a well-known and recognized distinct lymphoma entity. More recently, additional lymphomas have been reported in relation to prosthesis other than breast implants, as these allow the pericyte to develop into a clone that undergoes a maturation process, progressing toward full malignancy. Methods: We performed a systematic review with a descriptive analysis of data extracted from primary studies following PRISMA guidelines, including the search string “(IMPLANT* OR PROSTHES*) AND LYMPHOM*” in the PubMed, Scopus, Embase, and Google-Scholar databases. Data such as patient sex, age, implant site, prosthesis material, and lymphoma type were analyzed. Statistical methods, including Student’s t-test and Fisher’s exact test, were employed to compare lymphoma characteristics, with significance set at a p-value < 0.05. Results: From a total of 5992 studies, we obtained 43 case reports and series on a total of 52 patients diagnosed with prosthesis-associated lymphomas. The majority of implant-related lymphoma cases (85%) were of the B-cell type, mostly fibrin-associated large B-cell lymphoma (LBCL). This lymphoma type was more associated with biological (non-human-derived biological tissue), metallic, and synthetic implants (synthesized from non-organic components) (p-value = 0.007). Patients with ALCL had equal frequencies of metal and silicone prostheses (37.5%, 3 cases each), followed by synthetic prostheses (25%, 2 cases). ALCL cases were most common at skeletal (50%) and muscular-cutaneous sites (25%), whereas B-cell lymphomas were predominantly found in cardiovascular implants (50%), followed by skeletal (27%) and muscular-cutaneous (21%) sites. Death attributed to lymphoma took place in 67% of the cases, mostly LBCL occurring in cardiovascular sites. Conclusions: Because the included studies were limited ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39682271; info:eu-repo/semantics/altIdentifier/wos/WOS:001376838500001; volume:16; issue:23; numberofpages:14; journal:CANCERS; https://hdl.handle.net/10447/694474 |
| DOI: |
10.3390/cancers16234085 |
| Availability: |
https://hdl.handle.net/10447/694474; https://doi.org/10.3390/cancers16234085 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C75626F3 |
| Database: |
BASE |