| Title: |
Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study |
| Authors: |
Del Percio C; Lizio R; Lopez S; Noce G; Jakhar D; Carpi M; Bolukbas B; Soricelli A; Salvatore M; Guntekin B; Yener G; Massa F; Arnaldi D; Fama F; Pardini M; Ferri R; Salerni M; Lanuzza B; Stocchi F; Vacca L; Coletti C; Marizzoni M; Taylor JP; Hanoglu L; Helvaci Yilmaz N; Kiyi I; Ozbek-Isbitiren Y; Frisoni GB; Cuoco S; Barone P; D'Anselmo A; Bonanni L; Biundo R; D'Antonio F; Bruno G; Giubilei F; De Pandis F; Rotondo R; Antonini A; Babiloni C |
| Source: |
Neurobiology of Disease, March 2025 |
| Publisher Information: |
Academic Press Inc. |
| Publication Year: |
2025 |
| Collection: |
Newcastle University Library ePrints Service |
| Description: |
© 2025 The Authors. Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8–10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/303993; https://eprints.ncl.ac.uk/fulltext.aspx?url=303993/31324595-51CD-44C9-B914-C316FB9F1783.pdf&pub_id=303993 |
| Availability: |
https://eprints.ncl.ac.uk/303993 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.C7894352 |
| Database: |
BASE |