| Title: |
The effect of anticancer therapy on anti-hepatitis B antibody titres in patients with haematological malignancies and solid tumours |
| Authors: |
Yilmaz, Bahiddin; Erdem, Dilek; Teker, Fatih; Goren, Ibrahim; Yildirim, Beytullah; Kut, Engin; Yucel, Idris |
| Contributors: |
OMÜ |
| Publisher Information: |
Sage Publications Ltd |
| Publication Year: |
2016 |
| Subject Terms: |
Hepatitis B virus reactivation; hepatitis B surface antibody; chemotherapy; solid tumour; haematological malignancy |
| Description: |
TEKER, FATIH/0000-0003-4693-6587 ; WOS: 000377346400021 ; PubMed: 27048386 ; Objective To investigate the effect of immunosuppressive anticancer therapy on titre levels of anti-hepatitis B surface antibodies (anti-HBs) in hepatitis B surface antigen (HBsAg) negative and anti-HBs positive patients with haematological malignancies or solid tumours. Methods This retrospective study reviewed the medical records of patients with haematological malignancies or solid tumours. Pretreatment HBsAg negative and anti-HBs positive patients were included in the analysis. Anti-hepatitis B core antibody status was used to evaluate vaccinated patients and those with resolved HBV infections. Results The medical records of 237 patients were reviewed retrospectively. The median anti-HBs titre decreased significantly after anticancer therapy compared with the pretreatment median anti-HBs titre in all patients (71mIU/ml versus 57mIU/ml). Anti-HBs titre decreased significantly in patients with haematological malignancies (70mIU/m versus 37mIU/ml) and in patients administered rituximab-based chemotherapy (67mIU/ml versus 33mIU/ml) following chemotherapy, whereas there was no significant change in patients with solid tumours. After chemotherapy, patients with low pretreatment anti-HBs titres ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of International Medical Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1177/0300060516638992; https://hdl.handle.net/20.500.12712/13324; 44; 627; 638 |
| DOI: |
10.1177/0300060516638992 |
| Availability: |
https://hdl.handle.net/20.500.12712/13324; https://doi.org/10.1177/0300060516638992 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C7E5ECBA |
| Database: |
BASE |