| Title: |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. |
| Authors: |
Karlsson Linnér, R; Biroli, P; Kong, E; Meddens, SFW; Wedow, R; Fontana, MA; Lebreton, M; Tino, SP; Abdellaoui, A; Hammerschlag, AR; Nivard, MG; Okbay, A; Rietveld, CA; Timshel, PN; Trzaskowski, M; Vlaming, RD; Zünd, CL; Bao, Y; Buzdugan, L; Caplin, AH; Chen, C-Y; Eibich, P; Fontanillas, P; Gonzalez, JR; Joshi, PK; Karhunen, V; Kleinman, A; Levin, RZ; Lill, CM; Meddens, GA; Muntané, G; Sanchez-Roige, S; Rooij, FJV; Taskesen, E; Wu, Y; Zhang, F; 23and Me Research Team; eQTLgen Consortium; International Cannabis Consortium; Social Science Genetic Association Consortium; Auton, A; Boardman, JD; Clark, DW; Conlin, A; Dolan, CC; Fischbacher, U; Groenen, PJF; Harris, KM; Hasler, G; Hofman, A; Ikram, MA; Jain, S; Karlsson, R; Kessler, RC; Kooyman, M; MacKillop, J; Männikkö, M; Morcillo-Suarez, C; McQueen, MB; Schmidt, KM; Smart, MC; Sutter, M; Thurik, AR; Uitterlinden, AG; White, J; Wit, HD; Yang, J; Bertram, L; Boomsma, DI; Esko, T; Fehr, E; Hinds, DA; Johannesson, M; Kumari, M; Laibson, D; Magnusson, PKE; Meyer, MN; Navarro, A; Palmer, AA; Pers, TH; Posthuma, D; Schunk, D; Stein, MB; Svento, R; Tiemeier, H; Timmers, PRHJ; Turley, P; Ursano, RJ; Wagner, GG; Wilson, JF; Gratten, J; Lee, JJ; Cesarini, D; Benjamin, DJ; Koellinger, PD; Beauchamp, JP |
| Source: |
ftleicester |
| Publisher Information: |
Nature Research (part of Springer Nature) |
| Publication Year: |
2019 |
| Subject Terms: |
Behavior; Case-Control Studies; Female; Genetic Loci; Genetic Predisposition to Disease; Genetics; Behavioral; Genome-Wide Association Study; Genotype; Humans; Male; Polymorphism; Single Nucleotide; psy; info |
| Description: |
GWAS summary statistics can be downloaded from http://www.thessgac.org/ data. SNP-level summary statistics from analyses based entirely or in part on 23andMe data can only be reported for up to 10,000 SNPs. For general risk tolerance, we provide association results for all SNPs that passed quality-control filters in a GWAS meta-analysis of general risk tolerance that excludes the research participants from 23andMe; we also provide association results from the complete GWAS (which includes data from 23andMe) for all lead SNPs identified in our discovery GWAS and MTAG analysis of general risk tolerance and for the 4,000 most significant SNPs in the meta-analysis of the discovery and replication GWAS of risk tolerance. For adventurousness, we provide association results from the complete GWAS (which includes only data from 23andMe) for all lead SNPs and for the next 4,000 most significant SNPs. For automobile speeding propensity, drinks per week, ever smoker, number of sexual partners, and the first PC of the four risky behaviors, we provide association results from the complete GWAS for all SNPs that passed quality-control filters. Contact information for the cohorts included in this paper can be found in the Supplementary Note. ; The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above. ; Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.nature.com/articles/s41588-018-0309-3 |
| Availability: |
https://www.nature.com/articles/s41588-018-0309-3 |
| Rights: |
other |
| Accession Number: |
edsbas.C814F0AE |
| Database: |
BASE |