| Title: |
Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia |
| Authors: |
Nyholm, Iiris; Hukkinen, Maria; Pihlajoki, Marjut; Davidson, Joseph R.; Tyraskis, Athanasios; Lohi, Jouko; Heikkilä, Päivi; Hänninen, Satu; Andersson, Noora; Eloranta, Katja; Carpén, Olli; Heikinheimo, Markku; Davenport, Mark; Pakarinen, Mikko P. |
| Source: |
Hepatology ; volume 77, issue 4, page 1263-1273 ; ISSN 0270-9139 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2023 |
| Description: |
Background and Aims: Outcomes after Kasai portoenterostomy (KPE) for biliary atresia remain highly variable for unclear reasons. As reliable early biomarkers predicting KPE outcomes are lacking, we studied the prognostic value of FGF19. Approach and Results: Serum and liver specimens, obtained from biliary atresia patients (N=87) at KPE or age-matched cholestatic controls (N=26) were included. Serum concentration of FGF19 and bile acids, liver mRNA expression of FGF19 , and key regulators of bile acid synthesis were related to KPE outcomes and liver histopathology. Immunohistochemistry and in situ hybridization were used for the localization of liver FGF19 expression. Serum levels (223 vs. 61 pg/mL, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/hep.0000000000000048 |
| DOI: |
10.1097/HEP.0000000000000048 |
| Availability: |
https://doi.org/10.1097/hep.0000000000000048; https://journals.lww.com/10.1097/HEP.0000000000000048 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.C81C3890 |
| Database: |
BASE |