| Title: |
Association of intraoperative end-tidal CO2 levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials |
| Authors: |
Nasa, Prashant; van Meenen, David M. P.; Paulus, Frederique; Ferrando, Carlos; Bluth, Thomas; Gama de Abreu, Marcelo; Ball, Lorenzo; Bossers, Sebastiaan M.; Schober, Patrick; Schultz, Marcus J.; Serpa Neto, Ary; Hemmes, Sabrine N. T.; Campos, Niklas S.; Librero, Julian; Pozo, Natividad; Mazzinari, Guido; Pelosi, Paolo; Neto, Ary Serpa; Severgnini, Paolo; Hollmann, Markus W.; Binnekade, Jan M.; Wrigge, Hermann; Canet, Jaume; Hiesmayr, Michael; Schmid, Werner; Tschernko, Edda; Jaber, Samir; Hedenstierna, Göran; Putensen, Christian; Marti, Agnes; Bacuzzi, Alessandro; Brodhun, Alexander; Molin, Alexandre; Merten, Alfred; Parera, Ana; Brunelli, Andrea; Cortegiani, Andrea; Güldner, Andreas; Reske, Andreas W.; Gratarola, Angelo; Giarratano, Antonino; Bastin, Bea; Heyse, Bjorn; Mazul-Sunko, Branka; Amantea, Bruno; Barberis, Bruno; Uhlig, Christopher; Marín, Conrado Minguez; Celentano, Cristian; La Bella, Daniela; D'Antini, David; Velghe, David; Sulemanji, Demet; De Robertis, Edoardo; Hartmann, Eric; Montalto, Francesca; Tropea, Francesco; Mills, Gary H.; Cinnella, Gilda; Della Rocca, Giorgio; Caggianelli, Girolamo; Pellerano, Giulia; Mollica, Giuseppina; Bugedo, Guillermo; Mulier, Jan-Paul; Vandenbrande, Jeroen; Geib, Johann; Yaqub, Jonathan; Florez, Jorge; Mayoral, Juan F.; Sprung, Juraj; Van Limmen, Jurgen; Bos, Lieuwe D. J.; de Baerdemaeker, Luc; Jamaer, Luc; Spagnolo, Luigi; Strys, Lydia; Gil, Manuel Granell; Vidal Melo, Marcos F.; Unzueta, Maria Carmen; Moral, Maria Victoria; Ferner, Marion; Weiss, Martin; Vanoni, Massimo; Schaefer, Maximilian S.; Prieto, Mercè; Grio, Michele; Spieth, Peter Markus; Simon, Philipp; Bodger, Phoebe; Sierra, Pilar; Laufenberg-Feldmann, Rita; Rusca, Roberta; Proietti, Rodolfo; Raineri, Santi Maurizio; Caroleo, Santo; Sabaté, Sergi; De Hert, Stefan; Pezzato, Stefano; Treschan, Tanja A.; Goranovic, Tatjana; Koch, Thea; Kiss, Thomas; Perilli, Valter; Cegarra, Virginia; Bobek, Ilona; Gregoretti, Cesare; Laffey, John; Licker, Marc-Joseph; Markstaller, Klaus; Matot, Idit; Mulier, Jan Paul; Rossaint, Rolf; Schmitt, Jochen; Senturk, Mert; Abelha, Fernando; Abitağaoğlu, Sühayla; Achilles, Marc; Adebesin, Afeez; Adriaensens, Ine; Fatima Akbar, Charles Ahene.; Al Harbi, Mohammed; Al Khoury al Kallab, Rita; Albanel, Xavier; Aldenkortt, Florence; Saleh Alfouzan, Rawan Abdullah; Alruqaie, Reef; Altermatt, Fernando; Luís de Castro Araujo, Bruno; Genaro, Arbesú; Artsi, Hanna; Omer Hilmi Ayanoglu, Caterina Aurilio.; Baig, Harris; Baird, Yolanda; Jaume Balust, Konstantin Balonov.; Banks, Samantha; Bao, Xiaodong; Baumgartner, Mélanie; Tortosa, Isabel Belda; Bergamaschi, Alice; Bergmann, Lars; Bigatello, Luca; Pérez, Elena Biosca; Birr, Katja; Bojaxhi, Elird; Bonenti, Chiara; Bonney, Iwona; Bos, Elke M. E.; Bowman, Sara; Braz, Leandro Gobbo; Brugnoni, Elisa; Brull, Sorin J.; Brunetti, Iole; Bruni, Andrea; Buenvenida, Shonie L.; Busch, Cornelius Johannes; Camerini, Giovanni; Capatti, Beatrice; Carmona, Javiera; Carungcong, Jaime; Carvalho, Marta; Cattan, Anat; Cavaleiro, Carla; Chiumello, Davide; Ciardo, Stefano; Coburn, Mark; Colella, Umberto; Contreras, Victor; Dincer, Pelin Corman; Cotter, Elizabeth; Crovetto, Marcia; Darrah, William; Davies, Simon; Del Cojo Peces, Enrique; Delphin, Ellise; Diaper, John; Junior, Paulo do Nascimento; Donatiello, Valerio; Dong, Jing; Dourado, Maria do Socorro; Dullenkopf, Alexander; Ebner, Felix; Elgendy, Hamed; Ellenberger, Christoph; Arı, Dilek Erdoğan; Ermert, Thomas; Farah, Fadi; Fernandez-Bustamante, Ana; Ferreira, Cristina; Fiore, Marco; Fonte, Ana; Palahí, Christina Fortià; Galimberti, Andrea; Garofano, Najia; Giaccari, Luca Gregorio; Gilsanz, Fernando; Girrbach, Felix; Gobbi, Luca; Godfried, Marc Bernard; Goettel, Nicolai; Goldstein, Peter A.; Goren, Or; Gorlin, Andrew; Manuel, Granell Gil; Graterol, Juan; Guyon, Pierre; Haire, Kevin; Harou, Philippe; Helf, Antonia; Hempel, Gunther; Hernández Cádiz, María José; Heyse, Björn; Huercio, Ivan; Ilievska, Jasmina; Jakus, Lien; Jeganath, Vijay; Jelting, Yvonne; Jung, Minoa; Kabon, Barbara; Kacha, Aalok; Ilić, Maja Karaman; Karuppiah, Arunthevaraja; Kavas, Ayse Duygu; Barcelos, Gleicy Keli; Kellogg, Todd A.; Kemper, Johann; Kerbrat, Romain; Khodr, Suraya; Kienbaum, Peter; Kir, Bunyamin; Kivrak, Selin; Klarić, Vlasta; Köksal, Ceren; Kowark, Ana; Kranke, Peter; Kuvaki, Bahar; Kuzmanovska, Biljana; Lange, Mirko; Freitas de Lemos, Marília; López-Baamonde, Manuel; López-Hernández, Antonio; Lopez-Martinez, Mercedes; Luise, Stéphane; MacGregor, Mark; Magalhães, Danielle; Maillard, Julien; Malerbi, Patrizia; Manimekalai, Natesan; Margarson, Michael; Martin, Archer K.; Martin, David P.; Martin, Yvette N.; Martínez-Ocon, Julia; Martin-Loeches, Ignacio; Maseda, Emilio; McAuliffe, Niamh; McKenzie, Travis J.; Medina, Paulina; Meersch, Melanie; Els Mertens. Bernd Meurer, Angelika Menzen.; Meyer-Treschan. Changhong Miao. Camilla Micalizzi, Tanja; Milić, Morena; Pinheiro Módolo, Norma Sueli; Moine, Pierre; Mölders, Patrick; Montero-Feijoo, Ana; Moret, Enrique; Muller, Markus K.; Murphy, Zoe; Nalwaya, Pramod; Navalesi Paolo, Filip Naumovski.; Navarro e Lima, Lais Helena; Adam, Višnja Nesek; Neumann, Claudia; Newell, Christopher; Nisnevitch, Zoulfira; Nizamuddin, Junaid; Novazzi, Cecilia; O'Connor, Michael; Oprea, Günther; Sungur, Mukadder Orhan; Özbilgin, Şule; Pace, Maria Caterina; Pacheco, Marcos; Packianathaswamy, Balaji; Gonzalez, Estefania Palma; Sebastián Paredes, Fotios Papaspyros.; Passavanti, Maria Beatrice; Pedemonte, Juan Cristobal; Sanja Peremin, Paolo Pelosi.; Philipsenburg, Christoph; Pinho, Daniela; Pinho, Silvia; Posthuma, Linda M.; Pota, Vincenzo; Preckel, Benedikt; Priani, Paolo; Rached, Mohamed Aymen; Radoeshki, Aleksandar; Ragazzi, Riccardo; Rajamanickam, Tamilselvan; Rajamohan, Arthi; Desikan Rangarajan. Christian Reiterer, Harish Ramakrishna.; Renew, J. Ross; Reynaud, Thomas; Rhys, Rhidian; Luisa Robitzky, Eva Rivas.; Francesca Rubulotta. S. Machado Humberto, Rolf Rossaint.; Catarina, S. Nunes; Sabbatini, Giovanni; Samuels, Jon D.; Sanahuja, Josep Martí; Sansone, Pasquale; Santos, Alice; Sayedalahl, Mohamed; Scharffenberg, Martin; Schiffer, Eduardom; Schliewe, Nadja; Schorer, Raoul; Schumann, Roman; Selmo, Gabriele; Sendra, Mar; Kate Shaw, Paolo Severgnini.; Abdulrazak Sibai. Philipp Simon, Mirjana Shosholcheva.; Simonassi, Francesca; Sinno, Claudia; Sivrikoz, Nukhet; Neil Smith, Vasiliki Skandalou.; Soares, Maria; Artiles, Tania Socorro; Castro. Miguel Sousa, Diogo Sousa; Juraj Sprung, Savino Spadaro.; Stamatakis, Emmanouil; Steiner, Luzius A.; Stevenazzi, Andrea; Suarez-de-la-Rica. Mélanie Suppan, Alejandro; Teichmann, Robert; Tena Guerrero. Bram Thiel, José Maria; Tolós, Raquel; Altun, Gulbin Tore; Tucci, Michelle; Turnbull, Zachary A.; Turudić, Žana; Unterberg, Matthias; Van Nieuwenhove, Yves; Van Waesberghe, Julia; Vidal Melo. Bibiana Vitković, Marcos Francisco; Vivona, Luigi; Carlo Alberto Volta, Marcela Vizcaychipi.; Weber, Anne; Weingarten, Toby N.; Wittenstein, Jakob; Wyffels, Piet; Yagüe, Julio; Yates, David; Yavru, Ayşen; Zac, Lilach; Zhong, Jing; Belda, Javier; Soro, Marina; Unzueta, Carmen; Suarez-Sipmann, Fernando; Librero, Julián; Llombart, Alicia; Rovira, Lucas; Granell, Manuel; Aldecoa, César; Diaz-Cambronero, Oscar; Balust, Jaume; Garutti, Ignacio; Gonzalez, Rafael; Gallego, Lucia; Garcia del Valle, Santiago; Redondo, Javier; Pestaña, David; Rodríguez, Aurelio; García, Javier; Matta, Manuel de la; Ibáñez, Maite; Barrios, Francisco; Hernández, Samuel; Torres, Vicente; Peiró, Salvador; Villena, Abigail; Carramiñana, Albert; Gallego-Casilda, Alberto; Duca, Alejandro; Alcón, Amalia; Miñana, Amanda; Asensio, Ana; Colás, Ana; Galve, Ana Isabel; Izquierdo, Ana; Jurado, Ana; Pérez, Ana María; Mugarra, Ana; Gutierrez, Andrea; De Miguel, Ángeles; Lozano, Angels; Katime, Antonio; Romero, Antonio; Garrigues, Beatriz; Ayas, Begoña; Arocas, Blanca; Delgado, Carlos; Fernández, Carmen; Romero, Carolina; Gallego, Clara; Garcés, Cristina; Lisbona, Cristina; Parrilla, Cristina; López-Herrera, Daniel; González, Domingo; Llamazares, Eduardo; Del Rio, Elena; Lozano, Elena; Pastor, Ernesto; Chamorro, Estefanía; Gracia, Estefanía; Sánchez, Ester; Romero, Esther; Díez, Fernando; Serralta, Ferran; Daviu, Francisco; Sandín, Francisco; Aguilar, Gerardo; Tusman, Gerardo; Azparren, Gonzalo; Martínez-Pallí, Graciela; Benítez, Inmaculada; Hernandéz, Inmaculada; India, Inmaculada; León, Irene; Fuentes, Isabel; Ruiz, Isabel; Puig, Jaume; Román, Javie Ignacio; Acosta, Jesús; Rico-Feijoo, Jesús; Olmedo, Jonathan; Carbonell, Jose A.; Alonso, Jose M.; Pérez, Jose María; Marcos, Jose Miguel; Navarro, Jose; Valdivia, Jose; Carrizo, Juan; Piqueras, Laura; Soriano, Laura; Vaquero, Laura; Miguel, Lisset; Muñoz, Lorena; Valencia, Lucia; Olmedilla, Luis; Etulain, Ma Justina; Tisner, Manuel; Barrio, María; Alonso, María Dolores; García, María; Hernández, María J.; Alberola, María José; Parra, María; Argente, María Pilar; Vila, María; De Fez, Mario; Agilaga, Marta; Gine, Marta; Ayuso, Mercedes; García, Mercedes; Bejarano, Natalia; Peña, Natalia; Ojeda, Nazario; Martínez, Nilda; García, Nuria; Padrón, Oto; García, Pablo; Valls, Paola; Cruz, Patricia; Piñeiro, Patricia; Charco, Pedro; Anaya, Rafael; López, Ramiro; Rodríguez, Rayco; Martínez, Rocío; Pujol, Roger; Dosdá, Rosa; Lardies, Rosa; Díaz, Ruben; Villazala, Rubén; Zapatero, Sara; Cabrera, Sergio; Sánchez, Sergio; Martin, Silvia; Diaz, Suzana; Franco, Tania; Moreno, Tania; Socorro, Tania; Gilabert, Vicente; Balandrón, Victor; Moral, Victoria; Cegarra, Virgina; Varón, Viviana |
| Contributors: |
Nasa, Prashant; Van Meenen, David M. P.; Paulus, Frederique; Ferrando, Carlo; Bluth, Thoma; Gama De Abreu, Marcelo; Ball, Lorenzo; Bossers, Sebastiaan M.; Schober, Patrick; Schultz, Marcus J.; Serpa Neto, Ary; Hemmes, Sabrine N. T.; Campos, Niklas S.; Librero, Julian; Pozo, Natividad; Mazzinari, Guido; Pelosi, Paolo; Neto, Ary Serpa; Severgnini, Paolo; Hollmann, Markus W.; Binnekade, Jan M.; Wrigge, Hermann; Canet, Jaume; Hiesmayr, Michael; Schmid, Werner; Tschernko, Edda; Jaber, Samir; Hedenstierna, Göran; Putensen, Christian; Marti, Agne; Bacuzzi, Alessandro; Brodhun, Alexander; Molin, Alexandre; Merten, Alfred; Parera, Ana; Brunelli, Andrea; Cortegiani, Andrea; Güldner, Andrea; Reske, Andreas W.; Gratarola, Angelo; Giarratano, Antonino; Bastin, Bea; Heyse, Bjorn; Mazul-Sunko, Branka; Amantea, Bruno; Barberis, Bruno; Uhlig, Christopher; Marín, Conrado Minguez; Celentano, Cristian; La Bella, Daniela; D'Antini, David; Velghe, David; Sulemanji, Demet; De Robertis, Edoardo; Hartmann, Eric; Montalto, Francesca; Tropea, Francesco; Mills, Gary H.; Cinnella, Gilda; Della Rocca, Giorgio; Caggianelli, Girolamo; Pellerano, Giulia; Mollica, Giuseppina; Bugedo, Guillermo; Mulier, Jan-Paul; Vandenbrande, Jeroen; Geib, Johann; Yaqub, Jonathan; Florez, Jorge; Mayoral, Juan F.; Sprung, Juraj; Van Limmen, Jurgen; Bos, Lieuwe D. J.; De Baerdemaeker, Luc; Jamaer, Luc; Spagnolo, Luigi; Strys, Lydia; Gil, Manuel Granell; Vidal Melo, Marcos F.; Unzueta, Maria Carmen; Moral, Maria Victoria; Ferner, Marion; Weiss, Martin; Vanoni, Massimo; Schaefer, Maximilian S. |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Perugia |
| Subject Terms: |
PPCs; anaesthesia; carbon dioxide; end-tidal CO(2); etCO(2); intraoperative ventilation; invasive ventilation; postoperative pulmonary complications |
| Description: |
Background: The relationship between intraoperative end-tidal CO2 (etCO2) levels and postoperative outcomes remains unclear. We conducted a post hoc analysis of two randomised trials in adults undergoing major surgery under general anaesthesia. Methods: We re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese (PROVHILO: ISRCTN70332574) and obese (PROBESE: NCT02148692) patients. The exposure of interest was low etCO2 ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40930872; info:eu-repo/semantics/altIdentifier/wos/WOS:001628857100015; volume:135; issue:6; firstpage:1761; lastpage:1769; numberofpages:9; journal:BRITISH JOURNAL OF ANAESTHESIA; https://hdl.handle.net/11391/1615736 |
| DOI: |
10.1016/j.bja.2025.07.076 |
| Availability: |
https://hdl.handle.net/11391/1615736; https://doi.org/10.1016/j.bja.2025.07.076 |
| Accession Number: |
edsbas.C85C987D |
| Database: |
BASE |