Additional file 9 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 9 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
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| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 9: Fig. S8 Afatinib induces acute kinome rewiring in resistant clones. K-means clustering identifies upregulated “up” or downregulated “down” DE kinase proteins after drug treatment. Heatmaps of DE kinases after drug treatment are shown for the following resistant lines compared to parental CEv3 cells: E4 (A), E5 (B), G1 (C), G5 (D), G8 (E), and G12 (F) |
| Document Type: | still image |
| Language: | unknown |
| DOI: | 10.6084/m9.figshare.29432014.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29432014.v1; https://figshare.com/articles/figure/Additional_file_9_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29432014 |
| Rights: | CC BY |
| Accession Number: | edsbas.C85D37FC |
| Database: | BASE |