| Title: |
Catheter-associated thrombogenicity : exploring its mechanisms and pharmacological mitigation |
| Authors: |
Hardy, Michael |
| Contributors: |
UCL - SSS/IREC/MONT - Pôle Mont Godinne; UCL - Faculté de médecine et médecine dentaire; Pouleur, Anne-Catherine; Douxfils, Jonathan; Mullier, François; Lessire, Sarah; Momeni, Mona; Beauloye, Christophe; Lecompte, Thomas; Spronk, Henri; Vanassche, Thomas |
| Publication Year: |
2025 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Subject Terms: |
Direct oral anticoagulants; Thrombosis; Contact; Catheter; Coagulation; Hemostasis; Platelets; Thrombin generation; Heparin; Factor XIa inhibitors |
| Description: |
Thrombosis associated with medical devices, such as catheters, extracorporeal circuits, or mechanical heart valves, is a dreaded complication whose mechanisms and optimal means of pharmacological mitigation are still poorly studied. In this research project, we developed an experimental model to study thrombin generation on the surface of interventional cardiology catheter segments in the presence of platelets. Using this model, we could characterise the effect of the main classes of anticoagulants used clinically - heparins, direct oral anticoagulants, fondaparinux, and the newly marketed inhibitors of factors XI(a) and XII(a). We were able to confirm the central role of heparin in the prevention of foreign surface-associated thrombosis and to identify the factor XIIa inhibitor garadacimab and the factor XI and XIa inhibitors abelacimab as the most promising drugs in this setting. We were also able to glimpse fundamental differences between the activation of coagulation on a continuous surface, compared with an activator in solution, which we will need to explore in future work. ; (MED - Sciences médicales) -- UCL, 2025 |
| Document Type: |
doctoral or postdoctoral thesis |
| Language: |
English |
| Relation: |
boreal:300429; http://hdl.handle.net/2078.1/300429 |
| Availability: |
http://hdl.handle.net/2078.1/300429 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.C883CB41 |
| Database: |
BASE |